Loading
FUS (RNA-binding protein FUS) is a gene. The public catalogues list it as a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Sarcomas, Hepatocellular carcinoma and Liposarcoma.
DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3'. Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing.
Open Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.94, animal model 0.38, genetic association 0.00, somatic mutation 0.82). IntOGen calls it a driver in 1 cohort (0 activating, 0 loss-of-function), covering Hepatocellular Carcinoma.
In plain words · FUS (RNA-binding protein FUS) is a gene. The public catalogues list it as a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Sarcomas, Hepatocellular carcinoma and Liposarcoma.
FUS (RNA-binding protein FUS) is a gene. The public catalogues list it as a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Sarcomas, Hepatocellular carcinoma and Liposarcoma.
DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3'.
No product in this corpus aims at FUS yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1993. Earliest sequence paper UniProt cites for the protein: Crozat et al, Nature, 1993, "Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma". Source.
Sources: HGNC HGNC:4010 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P35637 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000089280 (association with cancer (MONDO_0004992) 0.64; per-cancer scores at or above 0.5: sarcoma 0.61, liposarcoma 0.56 (GraphQL API, CC0)); IntOGen FUS (driver in 1 cohort (Act 0, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3'. Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing. Also binds its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay. Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair. In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis. Location: Nucleus (UniProt). Locus 16p11.2 (HGNC).
Query for this target: (TITLE:"FUS" OR ABSTRACT:"FUS" OR TITLE:"FUS RNA binding protein" OR ABSTRACT:"FUS RNA binding protein" OR TITLE:"RNA-binding protein FUS" OR ABSTRACT:"RNA-binding protein FUS" OR TITLE:"FUS1" OR ABSTRACT:"FUS1" OR TITLE:"hnRNP-P2" OR ABSTRACT:"hnRNP-P2" OR TITLE:"HNRNPP2" OR ABSTRACT:"HNRNPP2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FUS, not a curated reading list.
Shares Liposarcoma, Sarcomas (soft tissue, bone, GIST), IntOGen.
Shares Liposarcoma, Sarcomas (soft tissue, bone, GIST), Open Targets Platform.
Shares Liposarcoma, Sarcomas (soft tissue, bone, GIST), IntOGen.