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ACSL6 (Long-chain-fatty-acid--CoA ligase 6) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Sarcomas and Liposarcoma.
Catalyses the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation. Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilised exclusively for the synthesis of the brain lipid.
IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Liposarcoma.
In plain words · ACSL6 (Long-chain-fatty-acid--CoA ligase 6) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Sarcomas and Liposarcoma.
ACSL6 (Long-chain-fatty-acid--CoA ligase 6) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Sarcomas and Liposarcoma.
Catalyses the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation.
No product in this corpus aims at ACSL6 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 1998. Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 1998, "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". Source.
Sources: HGNC HGNC:16496 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9UKU0 (protein name, function text, keywords and locations (REST API)); IntOGen ACSL6 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Catalyses the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation. Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilised exclusively for the synthesis of the brain lipid. Location: Mitochondrion outer membrane; Peroxisome membrane; Microsome membrane; Endoplasmic reticulum membrane (UniProt). Locus 5q31.1 (HGNC).
Query for this target: (TITLE:"ACSL6" OR ABSTRACT:"ACSL6" OR TITLE:"acyl-CoA synthetase long chain family member 6" OR ABSTRACT:"acyl-CoA synthetase long chain family member 6" OR TITLE:"Long-chain-fatty-acid--CoA ligase 6" OR ABSTRACT:"Long-chain-fatty-acid--CoA ligase 6" OR TITLE:"KIAA0837" OR ABSTRACT:"KIAA0837" OR TITLE:"ACS2" OR ABSTRACT:"ACS2" OR TITLE:"LACS5" OR ABSTRACT:"LACS5") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ACSL6, not a curated reading list.
Shares Liposarcoma, Sarcomas (soft tissue, bone, GIST), IntOGen.
Shares Liposarcoma, Sarcomas (soft tissue, bone, GIST), IntOGen.