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MB21D2 (Nucleotidyltransferase MB21D2) is an enzyme. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Head and neck squamous cell carcinoma, Sarcomas, Bladder & urothelial cancer and 2 more.
Probable nucleotidyltransferase that catalyses the formation of cyclic dinucleotide second messenger in response to some unknown stimulus.
IntOGen calls it a driver in 4 cohorts (1 activating, 3 loss-of-function), covering Head and Neck Squamous Cell Carcinoma, Liposarcoma, Lung Squamous Cell Carcinoma, Upper Tract Urothelial Carcinoma.
In plain words · MB21D2 (Nucleotidyltransferase MB21D2) is an enzyme. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Head and neck squamous cell carcinoma, Sarcomas, Bladder & urothelial cancer and 2 more.
MB21D2 (Nucleotidyltransferase MB21D2) is an enzyme. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Head and neck squamous cell carcinoma, Sarcomas, Bladder & urothelial cancer and 2 more.
Probable nucleotidyltransferase that catalyses the formation of cyclic dinucleotide second messenger in response to some unknown stimulus. Locus 3q29 (HGNC).
No product in this corpus aims at MB21D2 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
First described 2004. Earliest sequence paper UniProt cites for the protein: Genome Res, 2004, "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Source.
Sources: HGNC HGNC:30438 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q8IYB1 (protein name, function text, keywords and locations (REST API)); IntOGen MB21D2 (driver in 4 cohorts (Act 1, LoF 3); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Probable nucleotidyltransferase that catalyses the formation of cyclic dinucleotide second messenger in response to some unknown stimulus. Locus 3q29 (HGNC).
Query for this target: (TITLE:"MB21D2" OR ABSTRACT:"MB21D2" OR TITLE:"Mab-21 domain containing 2" OR ABSTRACT:"Mab-21 domain containing 2" OR TITLE:"Nucleotidyltransferase MB21D2" OR ABSTRACT:"Nucleotidyltransferase MB21D2" OR TITLE:"D2A" OR ABSTRACT:"D2A" OR TITLE:"C3orf59" OR ABSTRACT:"C3orf59") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MB21D2, not a curated reading list.
Shares Liposarcoma, Sarcomas (soft tissue, bone, GIST), IntOGen.
Shares Liposarcoma, Sarcomas (soft tissue, bone, GIST), IntOGen.