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DDIT3 (DDIT3 upstream open reading frame protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Sarcomas and Liposarcoma.
Product of the upstream open reading frame (uORF) of DDIT3/CHOP that is specifically produced in absence of stress, thereby preventing translation of downstream stress effector DDIT3/CHOP.
Open Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.98, genetic association 0.00, somatic mutation 0.97, genetic literature 0.30).
In plain words · DDIT3 (DDIT3 upstream open reading frame protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Sarcomas and Liposarcoma.
DDIT3 (DDIT3 upstream open reading frame protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Sarcomas and Liposarcoma.
Product of the upstream open reading frame (uORF) of DDIT3/CHOP that is specifically produced in absence of stress, thereby preventing translation of downstream stress effector DDIT3/CHOP. Location: Nucleus; Cytoplasm (UniProt).
No product in this corpus aims at DDIT3 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 2006. Earliest sequence paper UniProt cites for the protein: Scherer S.E. et al, Nature, 2006, "The finished DNA sequence of human chromosome 12". Source.
Sources: HGNC HGNC:2726 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P0DPQ6 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000175197 (association with cancer (MONDO_0004992) 0.65; per-cancer scores at or above 0.5: sarcoma 0.63, liposarcoma 0.60 (GraphQL API, CC0))
Product of the upstream open reading frame (uORF) of DDIT3/CHOP that is specifically produced in absence of stress, thereby preventing translation of downstream stress effector DDIT3/CHOP. Location: Nucleus; Cytoplasm (UniProt). Locus 12q13.3 (HGNC).
Query for this target: (TITLE:"DDIT3" OR ABSTRACT:"DDIT3" OR TITLE:"DNA damage inducible transcript 3" OR ABSTRACT:"DNA damage inducible transcript 3" OR TITLE:"DDIT3 upstream open reading frame protein" OR ABSTRACT:"DDIT3 upstream open reading frame protein" OR TITLE:"CHOP10" OR ABSTRACT:"CHOP10" OR TITLE:"GADD153" OR ABSTRACT:"GADD153") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about DDIT3, not a curated reading list.
Shares Liposarcoma, Sarcomas (soft tissue, bone, GIST), Open Targets Platform.