{"entity":{"id":"acsl6","kind":"target","name":"ACSL6","aka":["acyl-CoA synthetase long chain family member 6","Long-chain-fatty-acid--CoA ligase 6","KIAA0837","ACS2","LACS5","LACS2","FACL6"],"tldr":"ACSL6 (Long-chain-fatty-acid--CoA ligase 6) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Sarcomas and Liposarcoma.","summary":"Catalyses the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation. Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilised exclusively for the synthesis of the brain lipid.\n\nIntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Liposarcoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:16496","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16496"},{"label":"UniProt Q9UKU0","url":"https://www.uniprot.org/uniprotkb/Q9UKU0/entry"},{"label":"NCBI Gene 23305","url":"https://www.ncbi.nlm.nih.gov/gene/23305"},{"label":"Ensembl ENSG00000164398","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000164398"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["sarcoma","liposarcoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ACSL6","role":["oncogene-driver","fusion-partner"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:16496","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16496","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9UKU0","url":"https://www.uniprot.org/uniprotkb/Q9UKU0/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen ACSL6","url":"https://www.intogen.org/search?gene=ACSL6","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"specificitySources":[],"hgnc":"HGNC:16496","ensembl":"ENSG00000164398","uniprot":"Q9UKU0","entrez":"23305","firstDescribed":1998,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 1998, \"Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/10048485/","biology":"Catalyses the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation. Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilised exclusively for the synthesis of the brain lipid. Location: Mitochondrion outer membrane; Peroxisome membrane; Microsome membrane; Endoplasmic reticulum membrane (UniProt). Locus 5q31.1 (HGNC).","whereFound":["Sarcomas: IntOGen driver in 1 cohort (LIPO)","Liposarcoma: IntOGen driver in 1 cohort (LIPO)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/acsl6/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"liposarcoma","kind":"cancer","name":"Liposarcoma","route":"/cancers/liposarcoma/"},{"id":"sarcoma","kind":"cancer","name":"Sarcomas (soft tissue, bone, GIST)","route":"/cancers/sarcoma/"}]}}