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FES (Tyrosine-protein kinase Fes/Fps) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer, Leukaemia and Colorectal cancer.
Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signalling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT.
Open Targets scores its association with cancer at 0.69 (direct and indirect evidence; datatypes literature 0.68, animal model 0.43, genetic association 0.47, somatic mutation 0.97). In OnCo, 1 product record names it (Fluoroestradiol F-18 (FES PET)).
In plain words · FES (Tyrosine-protein kinase Fes/Fps) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer, Leukaemia and Colorectal cancer.
FES (Tyrosine-protein kinase Fes/Fps) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer, Leukaemia and Colorectal cancer.
Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading.
No product in this corpus aims at FES yet. Kinases are switched on by binding ATP inside the cell, so most drugs are small molecules shaped to plug that ATP pocket.
Lineage antigen shared with normal dendritic cells and granulocytes and monocytes and bone marrow cells and lymphoid tissue cells: HPA finds the gene tissue enhanced in bone marrow, lymphoid tissue, and the 1 medicine aimed at it (Fluoroestradiol F-18 (FES PET)) act on the wild-type protein, so the normal lineage is hit too. HPA FES: RNA tissue enhanced (bone marrow 79 nTPM, lymphoid tissue 110 nTPM); blood lineage group enriched (dendritic cells 163 nTPM, granulocytes 317 nTPM, monocytes 152 nTPM); high antibody staining in 1 normal tissue; highest cancer staining liver cancer (2 of 12 high). Distribution: 3 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Skin cancer (all types), Leukaemia, Colorectal cancer); approvals of single-target medicines aimed at it also list Breast cancer (all types), not counted; Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas FES tissue; Human Protein Atlas FES pathology; Open Targets ENSG00000182511 associations
First described 1985. Earliest sequence paper UniProt cites for the protein: Roebroek A.J.M. et al, EMBO J, 1985, "The structure of the human c-fes/fps proto-oncogene". Source.
Sources: HGNC HGNC:3657 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P07332 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000182511 (association with cancer (MONDO_0004992) 0.69; per-cancer scores at or above 0.5: colorectal cancer 0.50, skin cancer 0.53, leukaemia 0.52 (GraphQL API, CC0))
Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signalling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signalling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Location: Cytoplasm, cytosol; Cytoplasm, cytoskeleton; Cell membrane; Cytoplasmic vesicle (UniProt). Locus 15q26.1 (HGNC).
RNA: tissue enhanced (bone marrow 79 nTPM, lymphoid tissue 110 nTPM), detected in all normal tissues. Blood: group enriched (dendritic cells 163 nTPM, granulocytes 317 nTPM, monocytes 152 nTPM).
Medium: Adrenal gland, Cerebellum, Duodenum, Fallopian tube, Gallbladder, Heart muscle, Kidney, Liver.
Medium only: lymphoma, pancreatic cancer, renal cancer, stomach cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"FES" OR ABSTRACT:"FES" OR TITLE:"FES proto-oncogene, tyrosine kinase" OR ABSTRACT:"FES proto-oncogene, tyrosine kinase" OR TITLE:"Tyrosine-protein kinase Fes/Fps" OR ABSTRACT:"Tyrosine-protein kinase Fes/Fps") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FES, not a curated reading list.
Shares Diagnostic Accuracy and Safety Study of FES PET/CT in Assessment of ER Status of Recurrent or Metastatic Breast Cancer, [18F]Fluoroestradiol-PET/CT Imaging of Invasive Lobular Carcinoma, 18F-fluoroestradiol (FES) PET/CT for Breast Cancer.
Shares Leukaemia (all types), Skin cancer (all types), Open Targets Platform, Colorectal cancer.
Shares Leukaemia (all types), Skin cancer (all types), Open Targets Platform, Colorectal cancer.
Shares Leukaemia (all types), Skin cancer (all types), Open Targets Platform, Colorectal cancer.
Shares Leukaemia (all types), Skin cancer (all types), Open Targets Platform, Colorectal cancer.
Shares Leukaemia (all types), Skin cancer (all types), Open Targets Platform, Colorectal cancer.
Shares Leukaemia (all types), Skin cancer (all types), Open Targets Platform, Colorectal cancer.
Shares Leukaemia (all types), Skin cancer (all types), Open Targets Platform, Colorectal cancer.