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Timothy Ley led the first whole-genome sequencing of a cancer, an AML genome, in 2008.
Timothy J. Ley is the Lewis T. and Rosalind B. Apple Professor of Oncology at Siteman Cancer Center, Washington University. He is a haematologist-scientist who led the first whole-genome sequencing of a cancer, an acute myeloid leukaemia genome, in 2008, and went on to discover recurrent DNMT3A and IDH mutations in AML and to define clonal evolution at relapse. His selected papers report DNA sequencing of a cytogenetically normal AML genome and DNMT3A mutations in AML. He continues to work on AML genomics and clonal evolution.
| Title | Journal | Year |
|---|---|---|
| DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome | Nature | 2008 |
| DNMT3A mutations in acute myeloid leukemia | New England Journal of Medicine | 2010 |
Shares Siteman Cancer Center, Washington University, Whole-exome & whole-genome sequencing.
Shares Siteman Cancer Center, Washington University, Acute myeloid leukaemia.
Shares IDH1 / IDH2, Acute myeloid leukaemia.
Shares NPM1 mutation, Acute myeloid leukaemia.
Shares NPM1 mutation, Acute myeloid leukaemia.
Shares NPM1 mutation, Acute myeloid leukaemia.
Shares IDH1 / IDH2, Acute myeloid leukaemia.
Shares IDH1 / IDH2, Acute myeloid leukaemia.