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Dogs get cancers that closely resemble human ones, with real immune systems and years of natural history. Treating them, with owner consent, can test drugs in a way mice cannot.
Comparative oncology trials in client-owned dogs with spontaneous osteosarcoma, lymphoma, bladder cancer and glioma provide outbred, immunocompetent, spontaneously arising tumours with intact microenvironments. The NCI Comparative Oncology Trials Consortium has run such studies and informed human dosing for several agents. Capacity, standardisation and regulatory recognition, rather than concept, limit its use.
Shares Lab models that fail to predict what happens in patients, The valley of death between lab and product, National Cancer Institute (NIH).
Shares Lab models that fail to predict what happens in patients, The valley of death between lab and product, National Cancer Institute (NIH).
Shares Lab models that fail to predict what happens in patients, National Cancer Institute (NIH).
Shares Lab models that fail to predict what happens in patients, National Cancer Institute (NIH), Sarcomas (soft tissue, bone, GIST).
Shares The valley of death between lab and product, National Cancer Institute (NIH).
Shares Lab models that fail to predict what happens in patients, National Cancer Institute (NIH).
Shares Lab models that fail to predict what happens in patients, National Cancer Institute (NIH), Glioma & glioblastoma.
Shares Lab models that fail to predict what happens in patients, Sarcomas (soft tissue, bone, GIST), Glioma & glioblastoma.