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Trials
Sapanisertib and Serabelisib (PIKTOR) in Various Combinations in Patients With HR+/HER2- Advanced/Metastatic Breast Cancer

trialsTrialRecruiting

Sapanisertib and Serabelisib (PIKTOR) in Various Combinations in Patients With HR+/HER2- Advanced/Metastatic Breast Cancer

A phase 1/2 trial of Serabelisib, Sapanisertib and Fulvestrant in advanced solid tumours, run by Faeth Therapeutics, now recruiting.

Also called: PIKTOR

Overview Connected4

Overview

Sapanisertib and Serabelisib (PIKTOR) in Various Combinations in Patients With HR+/HER2- Advanced/Metastatic Breast Cancer is a phase 1/2 interventional study registered as NCT07558733 by Faeth Therapeutics, with 32 participants planned, started 2026-04-22 and due to reach its primary completion in 2029-05. Interventions recorded: Serabelisib, Sapanisertib and Fulvestrant.

Setting

Open-Label Umbrella Study to Evaluate Safety and Efficacy of Sapanisertib and Serabelisib (PIKTOR) in Various Combinations in Patients With HR+/HER2- Advanced or Metastatic Breast Cancer

Phase

Phase 1/2

Sponsor

Faeth Therapeutics

Registry

Started

2026-04-22

Enrolled

32 enrolled

Connected

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cancers

Metastatic cancer (cancer that has spread)

drugs

ApprovedInjectable SERD

Fulvestrant · Faslodex

Phase 2small molecule

Phase 2small molecule

Evidence strength21/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 1/2+8
32 enrolled+8
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0
A linked product is approved+5

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-18 · Jude Gomila · Trial acronyms for registry records · diff · file

Sources & links

ClinicalTrials.gov NCT07558733

Data

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Cancers

Metastatic cancer (cancer that has spread)

Products

Serabelisib
Sapanisertib
Fulvestrant

Not yet reviewedNeeds expert (clinical) review. Review this page or see the review queue and roster.

Model panel commentary is coming to this page: machine commentary, not clinical review.

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