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Trials
Study to Evaluate Efficacy & Safety of Afuresertib Plus Fulvestrant in Patients With Locally Advanced or Metastatic HR+/HER2- Breast Cancer

trialsTrialActive

Study to Evaluate Efficacy & Safety of Afuresertib Plus Fulvestrant in Patients With Locally Advanced or Metastatic HR+/HER2- Breast Cancer

A phase 3 trial of Afuresertib in advanced solid tumours, run by Laekna Limited, active and no longer recruiting.

Overview Connected3

Overview

Study to Evaluate Efficacy & Safety of Afuresertib Plus Fulvestrant in Patients With Locally Advanced or Metastatic HR+/HER2- Breast Cancer is a phase 3 interventional study registered as NCT04851613 by Laekna Limited, with 256 participants enrolled, started 2022-02-18 and due to reach its primary completion in 2026-10-30. Interventions recorded: Afuresertib and Afuresertib/placebo.

Setting

A Phase Ib/III Study to Evaluate the Efficacy and Safety of Afuresertib Plus Fulvestrant in Patients With Locally Advanced or Metastatic HR+/HER2- Breast Cancer Who Failed Standard of Care Therapies

Phase

Phase 3

Sponsor

Laekna Limited

Registry

Started

2022-02-18

Enrolled

256 enrolled

Connected

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cancers

Metastatic cancer (cancer that has spread)

technologies

Endocrine therapy (SERMs, AIs, SERDs)

drugs

ApprovedInjectable SERD

Fulvestrant · Faslodex

Evidence strength47/100 · Emerging

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 3+30
256 enrolled+12
No structured primary endpoint0
Result: active0
No independent replication recorded0
A linked product is approved+5

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-22 · Jude Gomila · Wave 2 corpus-only joins applied · diff · file

Sources & links

ClinicalTrials.gov NCT04851613

Data

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Cancers

Metastatic cancer (cancer that has spread)

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Endocrine therapy (SERMs, AIs, SERDs)

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Fulvestrant

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