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Sapanisertib is an experimental small-molecule drug from Faeth Therapeutics in phase 2 trials for HR-positive / HER2-negative breast cancer and endometrial cancer, aimed at mTOR.
Sapanisertib (FTH-003, MLN0128) is a small-molecule drug developed by Faeth Therapeutics. Its target is mTOR. ClinicalTrials.gov describes the intervention as: Sapanisertib is a small molecule inhibitor of the mammalian mTOR serine/threonine kinase. It is the investigational product in 2 recruiting or active industry-led phase 2 and phase 3 interventional cancer trials, in HR-positive / HER2-negative breast cancer and endometrial cancer. The largest, NCT06463028, plans to enrol 40 participants with primary completion expected 2028-09. Status reflects the highest phase registered on ClinicalTrials.gov; no efficacy results are recorded here.
Small-molecule drug directed at mTOR, as stated in the ClinicalTrials.gov intervention record; the detailed mechanism is not stated. Connects to mTOR.
1.Sapanisertib slips into a pocket on mTOR.
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Query for this drug: (TITLE:"Sapanisertib" OR ABSTRACT:"Sapanisertib" OR TITLE:"FTH-003" OR ABSTRACT:"FTH-003" OR TITLE:"MLN0128" OR ABSTRACT:"MLN0128") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Sapanisertib, not a curated reading list.
Shares Sapanisertib and Serabelisib (PIKTOR) in Various Combinations in Patients With HR+/HER2- Advanced/Metastatic Breast Cancer, Sapanisertib and Serabelisib (PIKTOR) With Paclitaxel and a Substudy With an Insulin-Suppressing Diet in Patients With Advanced/Recurrent Endometrial , Takeda, Endometrial cancer and the tag pipeline.
Shares Endometrial cancer, HR-positive / HER2-negative breast cancer and the tag pipeline.
Shares Takeda and the tag pipeline.
Shares Takeda and the tag pipeline.
Shares Takeda and the tag pipeline.
Shares Takeda and the tag pipeline.
Shares Takeda and the tag pipeline.
Shares Takeda and the tag pipeline.