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Trials
A Clinical Trial of Ifinatamab Deruxtecan in People With Advanced Esophageal Cancer (MK-3475-06F)

trialsTrialRecruiting

A Clinical Trial of Ifinatamab Deruxtecan in People With Advanced Esophageal Cancer (MK-3475-06F)

A phase 1/2 trial of I-DXd in oesophageal cancer, run by Merck Sharp & Dohme LLC, now recruiting.

Also called: KEYMAKER-U06

Overview Connected3

Overview

A Clinical Trial of Ifinatamab Deruxtecan in People With Advanced Esophageal Cancer (MK-3475-06F) is a phase 1/2 interventional study registered as NCT07405151 by Merck Sharp & Dohme LLC, with 60 participants planned, started 2026-03-27 and due to reach its primary completion in 2027-06-12. Interventions recorded: I-DXd and Rescue Medication.

Setting

A Phase 2 Open-Label, Umbrella Platform Design Study of Investigational Agent(s) in Participants With 2L/3L Unresectable Locally Advanced or Metastatic Esophageal Cancer: KEYMAKER-U06 Substudy 06F

Phase

Phase 1/2

Sponsor

Merck Sharp & Dohme LLC

Registry

Started

2026-03-27

Enrolled

60 enrolled

Connected

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cancers

Oesophageal cancer

companies

Daiichi Sankyo Merck & Co. (MSD)

Evidence strength17/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 1/2+8
60 enrolled+9
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-18 · Jude Gomila · Trial acronyms for registry records · diff · file

Sources & links

ClinicalTrials.gov NCT07405151

Data

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Cancers

Oesophageal cancer

Companies

Merck & Co. (MSD)
Daiichi Sankyo

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