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Trials
A Rollover Study Evaluating Sotorasib With or Without Panitumumab in Participants With KRAS p.G12C Mutation

trialsTrialRecruiting

A Rollover Study Evaluating Sotorasib With or Without Panitumumab in Participants With KRAS p.G12C Mutation

A phase 2 trial of Sotorasib and Panitumumab in advanced solid tumours, run by Amgen, now recruiting.

Overview Connected6

Overview

A Rollover Study Evaluating Sotorasib With or Without Panitumumab in Participants With KRAS p.G12C Mutation is a phase 2 interventional study registered as NCT07172919 by Amgen, with 14 participants planned, started 2026-01-02 and due to reach its primary completion in 2028-07-01. Interventions recorded: Sotorasib and Panitumumab.

Setting

A Rollover Study of Sotorasib With or Without Panitumumab for the Treatment of Cancer Subjects With KRAS p.G12C Mutation Previously Treated in an Amgen-Sponsored Study

Phase

Phase 2

Sponsor

Amgen

Registry

Started

2026-01-02

Enrolled

14 enrolled

Connected

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cancers

Metastatic cancer (cancer that has spread)

technologies

KRAS & RAS inhibitors Monoclonal antibodies

drugs

ApprovedMonoclonal antibody (anti-EGFR)

Panitumumab · Vectibix

ApprovedSmall-molecule inhibitor (KRAS G12C)

Sotorasib · Lumakras

companies

Evidence strength26/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 2+15
14 enrolled+6
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0
A linked product is approved+5

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-22 · Jude Gomila · Wave 2 corpus-only joins applied · diff · file

Sources & links

ClinicalTrials.gov NCT07172919

Data

JSON ·

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Cancers

Metastatic cancer (cancer that has spread)

Technologies

KRAS & RAS inhibitors
Monoclonal antibodies

Products

Sotorasib
Panitumumab

Companies

Amgen

Not yet reviewedNeeds expert (clinical) review. Review this page or see the review queue and roster.

Model panel commentary is coming to this page: machine commentary, not clinical review.

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