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Trials
A Clinical Study of Calderasib (MK-1084) in People With Advanced Solid Tumors (MK-1084-014)

trialsTrialRecruiting

A Clinical Study of Calderasib (MK-1084) in People With Advanced Solid Tumors (MK-1084-014)

A phase 2 trial of Calderasib and Cetuximab in advanced solid tumours, run by Merck Sharp & Dohme LLC, now recruiting.

Also called: KANDLELIT-014

Overview Connected5

Overview

A Clinical Study of Calderasib (MK-1084) in People With Advanced Solid Tumors (MK-1084-014) is a phase 2 interventional study registered as NCT07209111 by Merck Sharp & Dohme LLC, with 150 participants planned, started 2025-12-04 and due to reach its primary completion in 2032-04-09. Interventions recorded: Calderasib and Cetuximab.

Setting

A Phase 2, Open-Label, Multicenter, Tumor-agnostic Study of MK-1084 as Monotherapy and in Combination With Cetuximab, in Participants With KRAS G12C-Mutant, Advanced Solid Tumors (KANDLELIT-014)

Phase

Phase 2

Sponsor

Merck Sharp & Dohme LLC

Registry

Started

2025-12-04

Enrolled

150 enrolled

Connected

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cancers

Metastatic cancer (cancer that has spread)

technologies

Monoclonal antibodies

drugs

Phase 3small molecule

ApprovedMonoclonal antibody (anti-EGFR)

Cetuximab · Erbitux

companies

Merck & Co. (MSD)

Evidence strength31/100 · Emerging

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 2+15
150 enrolled+11
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0
A linked product is approved+5

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-22 · Jude Gomila · Wave 2 corpus-only joins applied · diff · file

Sources & links

ClinicalTrials.gov NCT07209111

Data

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Cancers

Metastatic cancer (cancer that has spread)

Technologies

Monoclonal antibodies

Products

Calderasib
Cetuximab

Companies

Merck & Co. (MSD)

Not yet reviewedNeeds expert (clinical) review. Review this page or see the review queue and roster.

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