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Trials
ABL103 in Combination With Pembrolizumab, With or Without Taxane in Advanced or Metastatic Solid Tumors

trialsTrialRecruiting

ABL103 in Combination With Pembrolizumab, With or Without Taxane in Advanced or Metastatic Solid Tumors

A phase 1/2 trial of Pembrolizumab in advanced solid tumours, run by ABL Bio, Inc., now recruiting.

Overview Connected4

Overview

ABL103 in Combination With Pembrolizumab, With or Without Taxane in Advanced or Metastatic Solid Tumors is a phase 1/2 interventional study registered as NCT07158918 by ABL Bio, Inc., with 65 participants planned, started 2025-08-06 and due to reach its primary completion in 2027-12-02. Interventions recorded: ABL103, KEYTRUDA® (pembrolizumab) and Taxane.

Setting

A Multicenter, Open-label, Phase 1b/2 Trial of ABL103, a Bispecific Antibody of B7-H4 and 4-1BB, in Combination With Pembrolizumab With/Without Taxane in Subjects With Selected, Progressive, Locally Advanced (Unresectable) or Metastatic Solid Tumors

Phase

Phase 1/2

Sponsor

ABL Bio, Inc.

Registry

Started

2025-08-06

Enrolled

65 enrolled

Connected

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cancers

Metastatic cancer (cancer that has spread)

technologies

Immune checkpoint inhibitors

drugs

ApprovedMonoclonal antibody (anti-PD-1)

Pembrolizumab · Keytruda / Keytruda Qlex (SC)

companies

Merck & Co. (MSD)

Evidence strength22/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 1/2+8
65 enrolled+9
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0
A linked product is approved+5

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-22 · Jude Gomila · Wave 2 corpus-only joins applied · diff · file

Sources & links

ClinicalTrials.gov NCT07158918

Data

JSON ·

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Cancers

Metastatic cancer (cancer that has spread)

Technologies

Immune checkpoint inhibitors

Products

Pembrolizumab

Companies

Merck & Co. (MSD)

Not yet reviewedNeeds expert (clinical) review. Review this page or see the review queue and roster.

Model panel commentary is coming to this page: machine commentary, not clinical review.

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