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Trials
Study to Evaluate the Long-term Safety of Rusfertide (PTG-300) in Subjects With Polycythemia Vera

trialsTrialActive

Study to Evaluate the Long-term Safety of Rusfertide (PTG-300) in Subjects With Polycythemia Vera

A phase 3 trial of Rusfertide in myeloproliferative neoplasms, run by Protagonist Therapeutics, Inc., active and no longer recruiting.

Also called: THRIVE

Overview Connected4

Overview

Study to Evaluate the Long-term Safety of Rusfertide (PTG-300) in Subjects With Polycythemia Vera is a phase 3 interventional study registered as NCT06033586 by Protagonist Therapeutics, Inc., with 46 participants enrolled, started 2024-01-22 and due to reach its primary completion in 2026-04-01. Interventions recorded: Open-label rusfertide.

Setting

An Extension Study to Evaluate the Long-term Safety of Rusfertide (PTG-300) in Subjects With Polycythemia Vera (THRIVE)

Phase

Phase 3

Sponsor

Protagonist Therapeutics, Inc.

Registry

Started

2024-01-22

Enrolled

46 enrolled

Connected

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cancers

Myeloproliferative neoplasms (PV, ET, myelofibrosis)

technologies

Peptide-drug & small-molecule-drug conjugates

drugs

ApprovedHepcidin mimetic peptide

Rusfertide · Mimrylo

companies

Protagonist Therapeutics

Evidence strength43/100 · Emerging

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 3+30
46 enrolled+8
No structured primary endpoint0
Result: active0
No independent replication recorded0
A linked product is approved+5

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-22 · Jude Gomila · Wave 2 corpus-only joins applied · diff · file

Sources & links

ClinicalTrials.gov NCT06033586

Data

JSON ·

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Cancers

Myeloproliferative neoplasms (PV, ET, myelofibrosis)

Technologies

Peptide-drug & small-molecule-drug conjugates

Products

Rusfertide

Companies

Protagonist Therapeutics

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