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Trials
Study to Assess SLN124 in Patients With Polycythemia Vera

trialsTrialActive

Study to Assess SLN124 in Patients With Polycythemia Vera

A phase 1/2 trial of SLN124 in myeloproliferative neoplasms, run by Silence Therapeutics plc, active and no longer recruiting.

Overview Connected1

Overview

Study to Assess SLN124 in Patients With Polycythemia Vera is a phase 1/2 interventional study registered as NCT05499013 by Silence Therapeutics plc, with 69 participants enrolled, started 2023-01-26 and due to reach its primary completion in 2026-09. Interventions recorded: SLN124 and Placebo.

Setting

Phase 1/2 Study With an Open-label Dose Escalation Phase Followed by a Randomized, Double-blind Phase of SLN124 in Patients With Polycythemia Vera

Phase

Phase 1/2

Sponsor

Silence Therapeutics plc

Registry

Started

2023-01-26

Enrolled

69 enrolled

Connected

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cancers

Myeloproliferative neoplasms (PV, ET, myelofibrosis)

Evidence strength17/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 1/2+8
69 enrolled+9
No structured primary endpoint0
Result: active0
No independent replication recorded0

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-16 · Jude Gomila · Registry trials wave 6 and products wave 7 · diff · file

Sources & links

ClinicalTrials.gov NCT05499013

Data

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Myeloproliferative neoplasms (PV, ET, myelofibrosis)

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