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Trials
Claudin18.2 CAR-T (CT041) in Patients With Gastric, Pancreatic Cancer, or Other Specified Digestive Cancers

trialsTrialActive

Claudin18.2 CAR-T (CT041) in Patients With Gastric, Pancreatic Cancer, or Other Specified Digestive Cancers

A phase 1/2 trial of CT041 in gastric & gastro-oesophageal junction cancer and pancreatic ductal adenocarcinoma, run by CARsgen Therapeutics Co., Ltd., active and no longer recruiting.

Overview Connected5

Overview

Claudin18.2 CAR-T (CT041) in Patients With Gastric, Pancreatic Cancer, or Other Specified Digestive Cancers is a phase 1/2 interventional study registered as NCT04404595 by CARsgen Therapeutics Co., Ltd., with 110 participants enrolled, started 2020-10-23 and due to reach its primary completion in 2025-06-01. Interventions recorded: CT041.

Setting

Open-label, Multicenter, Phase 1b/2 Clinical Trial to Evaluate the Safety and Efficacy of Autologous Anti-claudin 18.2 Chimeric Antigen Receptor T-cell Therapy in Subjects With Advanced Gastric, Pancreatic, or Other Specified Digestive System Cancers

Phase

Phase 1/2

Sponsor

CARsgen Therapeutics Co., Ltd.

Registry

Started

2020-10-23

Enrolled

110 enrolled

Connected

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cancers

Claudin 18.2-positive gastric cancer Gastric & gastro-oesophageal junction cancer Metastatic pancreatic ductal adenocarcinoma Pancreatic ductal adenocarcinoma

companies

CARsgen Therapeutics

Evidence strength18/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 1/2+8
110 enrolled+10
No structured primary endpoint0
Result: active0
No independent replication recorded0

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-18 · Jude Gomila · Add 11 pancreatic cancer subtype pages · diff · file

Sources & links

ClinicalTrials.gov NCT04404595

Data

JSON ·

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Cancers

Gastric & gastro-oesophageal junction cancer
Pancreatic ductal adenocarcinoma
Metastatic pancreatic ductal adenocarcinoma
Claudin 18.2-positive gastric cancer

Companies

CARsgen Therapeutics

Not yet reviewedNeeds expert (clinical) review. Review this page or see the review queue and roster.

Model panel commentary is coming to this page: machine commentary, not clinical review.

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