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Trials
HRS 4642 Injection Combined With AG Versus Placebo Combined With AG Therapy in First-Line Advanced or Metastatic Pancreatic Cancer

trialsTrialRecruiting

HRS 4642 Injection Combined With AG Versus Placebo Combined With AG Therapy in First-Line Advanced or Metastatic Pancreatic Cancer

A phase 3 trial of HRS-4642 + AG in pancreatic ductal adenocarcinoma, run by Jiangsu HengRui Medicine Co., Ltd., now recruiting.

Overview Connected3

Overview

HRS 4642 Injection Combined With AG Versus Placebo Combined With AG Therapy in First-Line Advanced or Metastatic Pancreatic Cancer is a phase 3 interventional study registered as NCT07232875 by Jiangsu HengRui Medicine Co., Ltd., with 588 participants planned, started 2025-11-21 and due to reach its primary completion in 2029-04. Interventions recorded: HRS-4642 + AG and HRS-4642 placebo + AG.

Setting

a Randomized, Controlled, Double-Blind, Multicenter Phase III Clinical Trial of HRS-4642 in Combination With Chemotherapy Versus Placebo in Combination With Chemotherapy as First-Line Therapy in Patients With Advanced or Metastatic Pancreatic Carcinoma Harboring KRAS G12D Gene Mutation

Phase

Phase 3

Sponsor

Jiangsu HengRui Medicine Co., Ltd.

Registry

Started

2025-11-21

Enrolled

588 enrolled

Connected

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cancers

Metastatic pancreatic ductal adenocarcinoma Pancreatic ductal adenocarcinoma

companies

Jiangsu Hengrui Pharmaceuticals

Evidence strength44/100 · Emerging

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 3+30
588 enrolled+14
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-22 · Jude Gomila · Registry trials now reach the 50 subtype pages added this… · diff · file

Sources & links

ClinicalTrials.gov NCT07232875

Data

JSON ·

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Cancers

Pancreatic ductal adenocarcinoma
Metastatic pancreatic ductal adenocarcinoma

Companies

Jiangsu Hengrui Pharmaceuticals

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