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MA.20, published alongside EORTC 22922, showed that adding nodal irradiation after lumpectomy improves disease-free survival, mainly by preventing distant spread, without a survival difference at ten years.
MA.20 randomised 1,832 women with node-positive or high-risk node-negative breast cancer treated by breast-conserving surgery and systemic therapy to whole-breast irradiation with or without regional nodal irradiation. Ten-year disease-free survival was 82.0 percent with nodal irradiation and 77.0 percent without (hazard ratio 0.76); overall survival did not differ (82.8 versus 81.8 percent), and lymphoedema and pneumonitis were more frequent (Whelan and colleagues, New England Journal of Medicine 2015).
Numbers are from the trial as recorded here; see the source links in the table below. This is orientation, not medical advice: ask your team how closely the trial population matches you.
1,832 enrolled.
| Endpoint | Arm | n | Value | HR (95% CI) | p | Source |
|---|---|---|---|---|---|---|
| Disease-free survival at 10 yearsprimary | Whole breast plus nodal irradiation | 916 | 82% | - | - | - |
| Whole-breast irradiation alone | 916 | 77% |
Shares HER2-positive breast cancer, IMRT / IGRT (modern external beam), Triple-negative breast cancer (TNBC), HR-positive / HER2-negative breast cancer and the tag radiation-wave4.
Shares IMRT / IGRT (modern external beam) and the tag radiation-wave4.
Shares IMRT / IGRT (modern external beam) and the tag radiation-wave4.
Shares IMRT / IGRT (modern external beam) and the tag radiation-wave4.
Shares IMRT / IGRT (modern external beam) and the tag radiation-wave4.
Shares IMRT / IGRT (modern external beam) and the tag radiation-wave4.
Shares IMRT / IGRT (modern external beam) and the tag radiation-wave4.
Shares IMRT / IGRT (modern external beam) and the tag radiation-wave4.