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EORTC 22922 showed that irradiating the internal mammary and supraclavicular nodes reduces breast cancer recurrence and death, with a small effect on overall survival, and made regional nodal irradiation standard for node-positive disease.
EORTC 22922/10925 randomised 4,004 women with node-positive or medially located early breast cancer to whole-breast or chest wall radiotherapy with or without irradiation of the internal mammary and medial supraclavicular nodes. Ten-year overall survival was 82.3 percent with nodal irradiation and 80.7 percent without (hazard ratio 0.87, borderline), with fewer distant recurrences and breast cancer deaths (Poortmans and colleagues, New England Journal of Medicine 2015); 15-year results confirmed lower breast cancer mortality without an overall survival difference.
Numbers are from the trial as recorded here; see the source links in the table below. This is orientation, not medical advice: ask your team how closely the trial population matches you.
4,004 enrolled.
| Endpoint | Arm | n | Value | HR (95% CI) | p | Source |
|---|---|---|---|---|---|---|
| Overall survival at 10 yearsprimary | Regional nodal irradiation | 2,002 | 82.3% | - | - | - |
| No nodal irradiation | 2,002 | 80.7% |
A second publication from the EORTC 22922 trial, later than the first and described in its title as an update or longer-term analysis. Read it with the primary publication linked from the trial page; the record was linked automatically and its figures have not been checked by hand.
This is the paper Europe PMC returns for registry id NCT00002851 with the most citations, so it is the natural first reading for anyone following the EORTC 22922 trial. Read the abstract above alongside the trial page and the registry entry; the record was linked automatically and its figures have not been checked by hand.
Shares HER2-positive breast cancer, IMRT / IGRT (modern external beam), Triple-negative breast cancer (TNBC), HR-positive / HER2-negative breast cancer and the tag radiation-wave4.
Shares EORTC, IMRT / IGRT (modern external beam) and the tag radiation-wave4.
Shares EORTC, IMRT / IGRT (modern external beam) and the tag radiation-wave4.
Shares EORTC and the tag radiation-wave4.
Shares IMRT / IGRT (modern external beam) and the tag radiation-wave4.
Shares IMRT / IGRT (modern external beam) and the tag radiation-wave4.
Shares IMRT / IGRT (modern external beam) and the tag radiation-wave4.
Shares IMRT / IGRT (modern external beam) and the tag radiation-wave4.