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The Danish postmastectomy trials proved that radiotherapy to the chest wall and nodes after mastectomy not only prevents local recurrence but saves lives in women with node-positive disease.
DBCG 82b randomised 1,708 premenopausal women with high-risk breast cancer to CMF chemotherapy with or without postmastectomy radiotherapy; 82c randomised 1,375 postmenopausal women to tamoxifen with or without radiotherapy. In 82b, ten-year locoregional recurrence fell from 32 to 9 percent and overall survival rose from 45 to 54 percent (Overgaard and colleagues, New England Journal of Medicine 1997); 82c showed the same pattern (Lancet 1999). Together with the British Columbia trial they established postmastectomy radiotherapy for node-positive disease.
Numbers are from the trial as recorded here; see the source links in the table below. This is orientation, not medical advice: ask your team how closely the trial population matches you.
3,083 enrolled.
| Endpoint | Arm | n | Value | HR (95% CI) | p | Source |
|---|---|---|---|---|---|---|
| Overall survival at 10 years (82b)primary | CMF plus postmastectomy radiotherapy | 852 | 54% | - | - | - |
| CMF alone | 856 | 45% |
Shares HER2-positive breast cancer, IMRT / IGRT (modern external beam), Triple-negative breast cancer (TNBC), HR-positive / HER2-negative breast cancer and the tag radiation-wave4.
Shares HER2-positive breast cancer, IMRT / IGRT (modern external beam), Triple-negative breast cancer (TNBC), HR-positive / HER2-negative breast cancer and the tag radiation-wave4.
Shares Fluorouracil (5-FU), IMRT / IGRT (modern external beam) and the tag radiation-wave4.
Shares Fluorouracil (5-FU), IMRT / IGRT (modern external beam) and the tag radiation-wave4.
Shares Fluorouracil (5-FU), IMRT / IGRT (modern external beam) and the tag radiation-wave4.
Shares Fluorouracil (5-FU), IMRT / IGRT (modern external beam) and the tag radiation-wave4.
Shares Fluorouracil (5-FU), IMRT / IGRT (modern external beam) and the tag radiation-wave4.
Shares IMRT / IGRT (modern external beam) and the tag radiation-wave4.