{"entity":{"id":"ma-20","kind":"trial","name":"NCIC MA.20","aka":[],"tldr":"MA.20, published alongside EORTC 22922, showed that adding nodal irradiation after lumpectomy improves disease-free survival, mainly by preventing distant spread, without a survival difference at ten years.","summary":"MA.20 randomised 1,832 women with node-positive or high-risk node-negative breast cancer treated by breast-conserving surgery and systemic therapy to whole-breast irradiation with or without regional nodal irradiation. Ten-year disease-free survival was 82.0 percent with nodal irradiation and 77.0 percent without (hazard ratio 0.76); overall survival did not differ (82.8 versus 81.8 percent), and lymphoedema and pneumonitis were more frequent (Whelan and colleagues, New England Journal of Medicine 2015).","status":"positive","asOf":"2026-09-17","links":[{"label":"ClinicalTrials.gov NCT00005957","url":"https://clinicaltrials.gov/study/NCT00005957"},{"label":"NEJM 2015","url":"https://doi.org/10.1056/NEJMoa1415340"}],"tags":["radiation-wave4"],"related":[],"cancers":["breast-hr-positive","breast-her2-positive","tnbc","breast-cancer"],"sections":[],"technologies":["imrt-igrt"],"targets":[],"drugs":[],"companies":["cctg"],"institutions":[],"pathways":[],"terms":["radiation-pneumonitis","post-mastectomy-radiotherapy"],"trials":["eortc-22922","supremo","nsabp-b51"],"people":[],"bottlenecks":[],"keyPapers":["paper-ma-20-n-engl-j-med-2015"],"journals":[],"dependsOn":[],"notes":[],"nct":"NCT00005957","phase":"3","setting":"Node-positive or high-risk node-negative breast cancer after breast-conserving surgery: whole-breast irradiation with or without regional nodal irradiation","sponsor":"Canadian Cancer Trials Group","result":"10-year disease-free survival 82.0% vs 77.0% (hazard ratio 0.76); overall survival unchanged.","started":"2000-03-09","startedType":"actual","yearReported":2015,"enrolled":1832,"enrolledBasis":"registry","outcomes":[{"endpoint":"Disease-free survival at 10 years","primary":true,"unit":"%","arms":[{"name":"Whole breast plus nodal irradiation","n":916,"value":82},{"name":"Whole-breast irradiation alone","n":916,"value":77}]}]},"route":"/trials/ma-20/","neighbours":{"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"breast-her2-positive","kind":"cancer","name":"HER2-positive breast cancer","route":"/cancers/breast-her2-positive/"},{"id":"breast-hr-positive","kind":"cancer","name":"HR-positive / HER2-negative breast cancer","route":"/cancers/breast-hr-positive/"},{"id":"tnbc","kind":"cancer","name":"Triple-negative breast cancer (TNBC)","route":"/cancers/tnbc/"}],"technology":[{"id":"imrt-igrt","kind":"technology","name":"IMRT / IGRT (modern external beam)","route":"/technologies/imrt-igrt/"}],"company":[{"id":"cctg","kind":"company","name":"Canadian Cancer Trials Group (CCTG)","route":"/companies/cctg/"}],"term":[{"id":"radiation-pneumonitis","kind":"term","name":"Radiation pneumonitis and lung fibrosis","route":"/terms/radiation-pneumonitis/"},{"id":"post-mastectomy-radiotherapy","kind":"term","name":"Radiotherapy after mastectomy","route":"/terms/post-mastectomy-radiotherapy/"}],"trial":[{"id":"eortc-22922","kind":"trial","name":"EORTC 22922/10925","route":"/trials/eortc-22922/"},{"id":"nsabp-b51","kind":"trial","name":"NSABP B-51 / RTOG 1304","route":"/trials/nsabp-b51/"},{"id":"supremo","kind":"trial","name":"SUPREMO (BIG 2-04)","route":"/trials/supremo/"}],"paper":[{"id":"paper-ma-20-n-engl-j-med-2015","kind":"paper","name":"Regional Nodal Irradiation in Early-Stage Breast Cancer","route":"/key-papers/paper-ma-20-n-engl-j-med-2015/"}]}}