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A carcinoma arising from the flat, layered cells that line surfaces exposed to wear: skin, mouth, throat, oesophagus, cervix, the larger airways. Often linked to tobacco, sun or HPV.
Squamous cells are stacked like tiles and make keratin, and their cancers keep enough of that character for pathologists to recognise them; the common causes are chronic irritation and carcinogens, which is why they dominate in smokers' airways and oesophagus, in sun-exposed skin, and in HPV-infected cervix, anus and throat. Squamous cancers share some biology across sites (frequent TP53 and CDKN2A loss, PIK3CA and FGFR1 changes) and have proven responsive to immunotherapy and, for skin, to cemiplimab. In lung cancer the label 'non-squamous' on a trial or drug label means adenocarcinoma and its relatives, and excludes squamous disease.
Backbone ribbon from PDB 8GY5. RCSB PDB 8GY5. The ribbon widens where the chain is folded into a regular pattern and narrows where it is a loose loop.
Showing the molecule this term concerns: Cemiplimab.
Shares Keratoacanthoma: the tumour that may be a squamous cell carcinoma, Keratinocyte cancer (and why 'non-melanoma skin cancer' is being retired), The subtype and grade on a cutaneous squamous cell carcinoma report, Bowen's disease (squamous cell carcinoma in situ).
Shares Keratoacanthoma: the tumour that may be a squamous cell carcinoma, Adenocarcinoma, The subtype and grade on a cutaneous squamous cell carcinoma report, Histology.
Shares Keratinocyte cancer (and why 'non-melanoma skin cancer' is being retired), The subtype and grade on a cutaneous squamous cell carcinoma report, Histology.
Shares Keratinocyte cancer (and why 'non-melanoma skin cancer' is being retired), The subtype and grade on a cutaneous squamous cell carcinoma report, Bowen's disease (squamous cell carcinoma in situ).
Shares HPV & HBV vaccination, Oesophageal cancer, Cervical cancer, Head and neck squamous cell carcinoma.
Shares HPV & HBV vaccination, Cervical cancer, Head and neck squamous cell carcinoma.
Shares Keratinocyte cancer (and why 'non-melanoma skin cancer' is being retired), Bowen's disease (squamous cell carcinoma in situ), HPV & HBV vaccination, Oesophageal cancer.
Shares Keratinocyte cancer (and why 'non-melanoma skin cancer' is being retired), Bowen's disease (squamous cell carcinoma in situ).