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A course of one to five large, pinpoint-accurate radiation doses that destroy a tumour outside the brain almost like surgery, for patients who cannot or prefer not to have an operation. It is standard for inoperable early lung cancer and the backbone of oligometastatic treatment; toxicity is mostly to whatever lies within a centimetre of the target.
Made possible by image guidance and motion management, SBRT gives local control above 90% for early lung cancer (the standard for inoperable stage I), treats liver, pancreatic, kidney, spine and prostate tumours (5-fraction PACE-B), and is the backbone of oligometastatic treatment, where SABR-COMET showed a survival gain. Ultra-high doses per fraction exploit different radiobiology (vascular damage, immune priming), hence the abscopal-effect trials with checkpoint inhibitors. Toxicity is mostly to whatever lies within a centimetre of the target.
Showing the technology this term belongs to: SBRT / SABR (stereotactic radiotherapy).
Shares Gray unit (Gy), IMRT / IGRT / VMAT (modern external beam radiotherapy), Re-irradiation, Hypofractionation (fewer, larger radiotherapy doses).
Shares Borderline resectable pancreatic ductal adenocarcinoma, Locally advanced unresectable pancreatic ductal adenocarcinoma, SBRT / SABR (stereotactic radiotherapy).
Shares Borderline resectable pancreatic ductal adenocarcinoma, Locally advanced unresectable pancreatic ductal adenocarcinoma, SBRT / SABR (stereotactic radiotherapy).
Shares Borderline resectable pancreatic ductal adenocarcinoma, Locally advanced unresectable pancreatic ductal adenocarcinoma, SBRT / SABR (stereotactic radiotherapy).
Shares Borderline resectable pancreatic ductal adenocarcinoma, Locally advanced unresectable pancreatic ductal adenocarcinoma, SBRT / SABR (stereotactic radiotherapy).
Shares David A. Palma, SBRT / SABR (stereotactic radiotherapy).
Shares Gray unit (Gy), Hypofractionation (fewer, larger radiotherapy doses), SBRT / SABR (stereotactic radiotherapy).
Shares Borderline resectable pancreatic ductal adenocarcinoma, Locally advanced unresectable pancreatic ductal adenocarcinoma.