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A single high dose of radiation delivered to a brain tumour or metastasis by beams converging from all sides, so the target gets a destructive dose while the surrounding brain gets little; no scalpel is involved despite the name. It treats metastases up to about 3-4 cm and has replaced whole-brain radiotherapy for limited disease because it spares cognition.
Gamma Knife, CyberKnife and linac-based SRS treat brain metastases up to about 3-4 cm (or several at once) with local control above 80% and have replaced whole-brain radiotherapy for limited disease because they spare cognition (N0574, JLGK0901). Larger cavities after surgery get fractionated stereotactic radiotherapy in 3-5 sessions. Modern practice combines SRS with CNS-active drugs (osimertinib, tucatinib, T-DXd), and trials now test whether upfront SRS can be deferred when such drugs are available.
Showing the technology this term belongs to: SBRT / SABR (stereotactic radiotherapy).
Shares Whole-brain radiotherapy (WBRT), Palliation in advanced triple-negative breast cancer: brain, bone, pleura, skin and end of life, HER2-positive breast cancer with brain metastases, Brain metastases (secondary brain tumours).
Shares Whole-brain radiotherapy (WBRT), Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission, Measure brain metastasis prevention as a primary endpoint, not as a secondary one, Gamma Knife.
Shares ZAP-X gyroscopic radiosurgery, Stereotactic radiosurgery (Gamma Knife, CyberKnife, linac SRS), SBRT / SABR (stereotactic radiotherapy).
Shares Vestibular schwannoma (acoustic neuroma), Meningioma, Brain metastases (secondary brain tumours), Stereotactic radiosurgery (Gamma Knife, CyberKnife, linac SRS).
Shares Brain metastases (secondary brain tumours), Brain metastases (intracranial disease), Stereotactic radiosurgery (Gamma Knife, CyberKnife, linac SRS), Lung cancer (all types).
Shares Alliance N0574 (NCCTG N0574), Brain metastases (secondary brain tumours).
Shares CyberKnife robotic radiosurgery, Stereotactic radiosurgery (Gamma Knife, CyberKnife, linac SRS), SBRT / SABR (stereotactic radiotherapy).
Shares CyberKnife robotic radiosurgery, Stereotactic radiosurgery (Gamma Knife, CyberKnife, linac SRS), SBRT / SABR (stereotactic radiotherapy).