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The common glandular-fever virus, carried lifelong by most adults, which in a minority of people drives nasopharyngeal cancer, some stomach cancers and several lymphomas.
EBV infects B cells and epithelium; it causes nearly all nasopharyngeal carcinoma (endemic in southern China), about 9% of gastric cancers (a TCGA subtype with high PD-L1 and immunotherapy sensitivity), Burkitt lymphoma, Hodgkin lymphoma in part, post-transplant lymphoproliferative disease and NK/T-cell lymphoma. Plasma EBV DNA screens for and monitors nasopharyngeal cancer; EBV-specific T cells (tabelecleucel) treat post-transplant lymphoma; EBV vaccines are in early trials. EBER in situ hybridisation is the tissue test.
Shares Primary effusion lymphoma, EBV-positive diffuse large B-cell lymphoma, Plasmablastic lymphoma, Monomorphic epitheliotropic intestinal T-cell lymphoma.
Shares EBV-positive diffuse large B-cell lymphoma, Post-transplant lymphoproliferative disorder (PTLD), HIV-associated (AIDS-related) lymphomas, Diffuse large B-cell lymphoma.
Shares EBV-positive diffuse large B-cell lymphoma, Plasmablastic lymphoma, Extranodal NK/T-cell lymphoma, Hodgkin lymphoma.
Shares HTLV-1 (human T-lymphotropic virus type 1), Primary effusion lymphoma, EBV-positive diffuse large B-cell lymphoma, Plasma EBV DNA.
Shares Primary effusion lymphoma, Plasmablastic lymphoma, Monomorphic epitheliotropic intestinal T-cell lymphoma, Extranodal NK/T-cell lymphoma.
Shares Plasma EBV DNA, Burkitt lymphoma, Hodgkin lymphoma, Diffuse large B-cell lymphoma.
Shares Primary effusion lymphoma, EBV-positive diffuse large B-cell lymphoma, Plasmablastic lymphoma, Monomorphic epitheliotropic intestinal T-cell lymphoma.
Shares Post-transplant lymphoproliferative disorder (PTLD), Burkitt lymphoma, Hodgkin lymphoma, Non-Hodgkin lymphoma (all types).