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Treatment given after a good response to kill the cancer cells that are presumably left but cannot be seen, to make the remission last. Durvalumab after chemoradiation for lung cancer is the best-known example.
In leukaemia, consolidation courses of cytarabine (or transplant) follow induction to eradicate residual disease. In lymphoma, radiotherapy to bulky sites or autologous transplant consolidates chemotherapy response; in myeloma, consolidation follows transplant before maintenance. In solid tumours the word entered common use with PACIFIC (a year of durvalumab after chemoradiation in stage III lung cancer) and ADRIATIC (durvalumab after chemoradiation in limited-stage small-cell lung cancer), and 'consolidative' SBRT or surgery to residual oligometastatic disease follows the same logic.
Backbone ribbon from PDB 5X8M. RCSB PDB 5X8M. The ribbon widens where the chain is folded into a regular pattern and narrows where it is a loose loop.
Showing the molecule this term concerns: Durvalumab.
Shares GEMSTONE-301, Unresectable stage III non-small-cell lung cancer, Durvalumab, Lung cancer (all types).
Shares PACIFIC, Unresectable stage III non-small-cell lung cancer, Durvalumab, Small-cell lung cancer.
Shares Limited-stage vs extensive-stage (small-cell lung cancer), Limited-stage small-cell lung cancer, Durvalumab, Small-cell lung cancer.
Shares CREST: consolidation thoracic radiotherapy in extensive-stage small-cell lung cancer, Extensive-stage small-cell lung cancer, Durvalumab, Small-cell lung cancer.
Shares CREST: consolidation thoracic radiotherapy in extensive-stage small-cell lung cancer, Extensive-stage small-cell lung cancer, Small-cell lung cancer, Lung cancer (all types).
Shares Limited-stage small-cell lung cancer, Unresectable stage III non-small-cell lung cancer, Small-cell lung cancer, Lung cancer (all types).
Shares PACIFIC, Unresectable stage III non-small-cell lung cancer, Chemoradiation (chemoradiotherapy, CRT), Durvalumab.
Shares Unresectable stage III non-small-cell lung cancer, Durvalumab, Small-cell lung cancer, Non-small-cell lung cancer.