{"entity":{"id":"consolidation-therapy","kind":"term","name":"Consolidation therapy","aka":["consolidation","consolidation chemotherapy","consolidation immunotherapy","post-remission therapy","intensification"],"tldr":"Treatment given after a good response to kill the cancer cells that are presumably left but cannot be seen, to make the remission last. Durvalumab after chemoradiation for lung cancer is the best-known example.","summary":"In leukaemia, consolidation courses of cytarabine (or transplant) follow induction to eradicate residual disease. In lymphoma, radiotherapy to bulky sites or autologous transplant consolidates chemotherapy response; in myeloma, consolidation follows transplant before maintenance. In solid tumours the word entered common use with PACIFIC (a year of durvalumab after chemoradiation in stage III lung cancer) and ADRIATIC (durvalumab after chemoradiation in limited-stage small-cell lung cancer), and 'consolidative' SBRT or surgery to residual oligometastatic disease follows the same logic.","asOf":"2026-09-09","wikipedia":"https://en.wikipedia.org/wiki/Consolidation_therapy","links":[{"label":"Wikipedia","url":"https://en.wikipedia.org/wiki/Consolidation_therapy"}],"tags":[],"related":["induction-therapy","maintenance-therapy","chemoradiation","oligometastatic"],"cancers":["nsclc","sclc","aml"],"sections":["chemotherapy","immunotherapy"],"technologies":[],"targets":[],"drugs":["durvalumab"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":["pacific"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"category":"Treatment jargon"},"route":"/terms/consolidation-therapy/","neighbours":{"term":[{"id":"chemoradiation","kind":"term","name":"Chemoradiation (chemoradiotherapy, CRT)","route":"/terms/chemoradiation/"},{"id":"induction-therapy","kind":"term","name":"Induction therapy","route":"/terms/induction-therapy/"},{"id":"limited-extensive-stage","kind":"term","name":"Limited-stage vs extensive-stage (small-cell lung cancer)","route":"/terms/limited-extensive-stage/"},{"id":"lymphoma-tx-maintenance","kind":"term","name":"Maintenance and consolidation in lymphoma: where it works and where it does not","route":"/terms/lymphoma-tx-maintenance/"},{"id":"maintenance-therapy","kind":"term","name":"Maintenance therapy","route":"/terms/maintenance-therapy/"},{"id":"oligometastatic","kind":"term","name":"Oligometastatic disease","route":"/terms/oligometastatic/"}],"cancer":[{"id":"aml","kind":"cancer","name":"Acute myeloid leukaemia","route":"/cancers/aml/"},{"id":"extensive-stage-sclc","kind":"cancer","name":"Extensive-stage small-cell lung cancer","route":"/cancers/extensive-stage-sclc/"},{"id":"limited-stage-sclc","kind":"cancer","name":"Limited-stage small-cell lung cancer","route":"/cancers/limited-stage-sclc/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"},{"id":"sclc","kind":"cancer","name":"Small-cell lung cancer","route":"/cancers/sclc/"},{"id":"stage-iii-unresectable-nsclc","kind":"cancer","name":"Unresectable stage III non-small-cell lung cancer","route":"/cancers/stage-iii-unresectable-nsclc/"}],"section":[{"id":"chemotherapy","kind":"section","name":"Chemotherapy","route":"/fronts/chemotherapy/"},{"id":"immunotherapy","kind":"section","name":"Immunotherapy","route":"/fronts/immunotherapy/"}],"drug":[{"id":"durvalumab","kind":"drug","name":"Durvalumab","route":"/drugs/durvalumab/"}],"trial":[{"id":"crest-thoracic-rt","kind":"trial","name":"CREST: consolidation thoracic radiotherapy in extensive-stage small-cell lung cancer","route":"/trials/crest-thoracic-rt/"},{"id":"gemstone-301","kind":"trial","name":"GEMSTONE-301","route":"/trials/gemstone-301/"},{"id":"pacific","kind":"trial","name":"PACIFIC","route":"/trials/pacific/"}]}}