Loading
Small-cell lung cancer uses a two-way split instead of the usual four stages: limited (confined to one side of the chest and treatable within one radiation field, about a third of patients) or extensive (everything else).
Limited-stage disease receives concurrent platinum-etoposide and thoracic radiotherapy (45 Gy twice daily or 60-70 Gy once daily) with curative intent, now followed by durvalumab consolidation (ADRIATIC), and cures 25-35%; extensive-stage disease receives platinum-etoposide with atezolizumab or durvalumab (IMpower133, CASPIAN), responds in most patients and relapses in most within a year, with tarlatamab now the preferred second-line drug. Prophylactic cranial irradiation or MRI surveillance follows response in both. TNM staging is applied in parallel but the two-stage system still drives treatment.
Backbone ribbon from PDB 5X8M. RCSB PDB 5X8M. The ribbon widens where the chain is folded into a regular pattern and narrows where it is a loose loop.
Showing the molecule this term concerns: Durvalumab.
Shares ADRIATIC, CONVERT, Platinum + etoposide (EP / CE), Limited-stage small-cell lung cancer.
Shares ADRIATIC, Prophylactic cranial irradiation vs MRI surveillance, Limited-stage small-cell lung cancer, Extensive-stage small-cell lung cancer.
Shares Platinum + etoposide (EP / CE), Tarlatamab, Extensive-stage small-cell lung cancer, Atezolizumab.
Shares Tarlatamab, Limited-stage small-cell lung cancer, Extensive-stage small-cell lung cancer, Atezolizumab.
Shares Serplulimab, Limited-stage small-cell lung cancer, Adebrelimab, Extensive-stage small-cell lung cancer.
Shares Serplulimab, Extensive-stage small-cell lung cancer, Atezolizumab, Small-cell lung cancer.
Shares Prophylactic cranial irradiation vs MRI surveillance, Limited-stage small-cell lung cancer, Extensive-stage small-cell lung cancer, Small-cell lung cancer.
Shares ADRIATIC, Prophylactic cranial irradiation vs MRI surveillance, Limited-stage small-cell lung cancer, Chemoradiation (chemoradiotherapy, CRT).