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Giving the brain a preventive dose of radiation (25 Gy in 10 sessions) before any metastasis can be seen, mainly in small-cell lung cancer, which spreads to the brain in over half of patients. Its value is disputed now that MRI surveillance is routine, and cognitive side effects push practice towards watching instead.
Small-cell lung cancer spreads to the brain in over half of patients, and PCI (25 Gy in 10 fractions) halved brain relapse and improved survival in limited-stage disease in the 1990s meta-analysis. Its value in extensive-stage disease and in the era of routine MRI staging is disputed (the Japanese Takahashi trial found no benefit with MRI surveillance), so the SWOG S1827 MAVERICK trial is comparing PCI with MRI surveillance while cognitive side effects push practice toward surveillance. In childhood leukaemia it has been replaced by intrathecal chemotherapy.
Shares ADRIATIC, Prophylactic cranial irradiation vs MRI surveillance, Limited-stage small-cell lung cancer, Extensive-stage small-cell lung cancer.
Shares Prophylactic cranial irradiation vs MRI surveillance, Limited-stage small-cell lung cancer, Extensive-stage small-cell lung cancer, Small-cell lung cancer.
Shares Whole-brain radiotherapy (WBRT), Prophylactic cranial irradiation vs MRI surveillance, Extensive-stage small-cell lung cancer, Small-cell lung cancer.
Shares Whole-brain radiotherapy (WBRT), Prophylactic cranial irradiation vs MRI surveillance, Extensive-stage small-cell lung cancer, Small-cell lung cancer.
Shares Intrathecal therapy (lumbar puncture, Ommaya reservoir), Whole-brain radiotherapy (WBRT), Brain metastases (intracranial disease).
Shares Brain metastases (intracranial disease), Limited-stage small-cell lung cancer, Extensive-stage small-cell lung cancer, Small-cell lung cancer.
Shares Prophylactic cranial irradiation vs MRI surveillance, Brain metastases (intracranial disease), Limited-stage small-cell lung cancer, Extensive-stage small-cell lung cancer.
Shares Extensive-stage small-cell lung cancer, Small-cell lung cancer.