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Giving drugs directly into the fluid around the brain and spinal cord, by needle in the lower back or through a small reservoir under the scalp, because most drugs cannot cross from the blood into that space.
Intrathecal methotrexate and cytarabine prevent and treat central nervous system leukaemia and lymphoma and are given by lumbar puncture, which also samples cerebrospinal fluid for leukaemic cells or ctDNA. An Ommaya reservoir connects to a ventricular catheter for repeated intraventricular dosing and is the route for locoregional CAR-T in glioblastoma and leptomeningeal disease trials. Intrathecal trastuzumab is used for HER2-positive leptomeningeal metastases.
Shares Primary large B-cell lymphoma of the testis, HIV-associated (AIDS-related) lymphomas, Primary CNS lymphoma, Diffuse large B-cell lymphoma.
Shares HIV-associated (AIDS-related) lymphomas, Burkitt lymphoma, Acute lymphoblastic leukaemia, Diffuse large B-cell lymphoma.
Shares CNS prophylaxis in aggressive B-cell lymphoma, and the evidence against it, HIV-associated (AIDS-related) lymphomas, Burkitt lymphoma, Diffuse large B-cell lymphoma.
Shares Primary CNS lymphoma, Burkitt lymphoma, Acute lymphoblastic leukaemia, Diffuse large B-cell lymphoma.
Shares Primary CNS lymphoma, Burkitt lymphoma, Acute lymphoblastic leukaemia, Diffuse large B-cell lymphoma.
Shares VCAP-AMP-VECP compared with biweekly CHOP for adult T-cell leukemia-lymphoma: Japan Clinical Oncology Group Study JCOG9801, JCOG9801.
Shares VCAP-AMP-VECP compared with biweekly CHOP for adult T-cell leukemia-lymphoma: Japan Clinical Oncology Group Study JCOG9801, JCOG9801.
Shares HIV-associated (AIDS-related) lymphomas, Burkitt lymphoma.