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Flushing, diarrhoea and wheezing caused by hormones (mostly serotonin) released by some neuroendocrine tumours; over years it can scar the heart valves.
Occurs in ~20-30% of small-bowel NETs, usually with liver metastases. Somatostatin analogues control symptoms; telotristat ethyl (tryptophan hydroxylase inhibitor, 2017) treats refractory diarrhoea; 24-hour urinary 5-HIAA monitors; echocardiography screens for right-heart valve disease. Carcinoid crisis during anaesthesia or embolisation is prevented with octreotide infusion.
Ball-and-stick model from PubChem 2D record (no 3D conformer available). PubChem record
Showing the molecule this term concerns: Somatostatin analogues (octreotide, lanreotide).
Shares Somatostatin analogues (octreotide, lanreotide), Lung neuroendocrine tumours (typical and atypical carcinoid), Neuroendocrine tumours.
Shares Tryptophan hydroxylase 1, Somatostatin analogues (octreotide, lanreotide), Small intestinal neuroendocrine tumours, Neuroendocrine tumours.
Shares Somatostatin analogues (octreotide, lanreotide), Lung neuroendocrine tumours (typical and atypical carcinoid), Small intestinal neuroendocrine tumours, Neuroendocrine tumours.
Shares Somatostatin analogues (octreotide, lanreotide), Small intestinal neuroendocrine tumours, Neuroendocrine tumours.
Shares Lung neuroendocrine tumours (typical and atypical carcinoid), Small intestinal neuroendocrine tumours, Neuroendocrine tumours.
Shares Lung neuroendocrine tumours (typical and atypical carcinoid), Small intestinal neuroendocrine tumours, Neuroendocrine tumours.
Shares Lung neuroendocrine tumours (typical and atypical carcinoid), Small intestinal neuroendocrine tumours.
Shares Lung neuroendocrine tumours (typical and atypical carcinoid), Small intestinal neuroendocrine tumours, Neuroendocrine tumours.