{"entity":{"id":"carcinoid-syndrome","kind":"term","name":"Carcinoid syndrome and carcinoid heart disease","aka":[],"tldr":"Flushing, diarrhoea and wheezing caused by hormones (mostly serotonin) released by some neuroendocrine tumours; over years it can scar the heart valves.","summary":"Occurs in ~20-30% of small-bowel NETs, usually with liver metastases. Somatostatin analogues control symptoms; telotristat ethyl (tryptophan hydroxylase inhibitor, 2017) treats refractory diarrhoea; 24-hour urinary 5-HIAA monitors; echocardiography screens for right-heart valve disease. Carcinoid crisis during anaesthesia or embolisation is prevented with octreotide infusion.","asOf":"2026-09-07","wikipedia":"https://en.wikipedia.org/wiki/Carcinoid_syndrome","links":[{"label":"Wikipedia","url":"https://en.wikipedia.org/wiki/Carcinoid_syndrome"}],"tags":[],"related":[],"cancers":["neuroendocrine","small-intestinal-net"],"sections":[],"technologies":[],"targets":[],"drugs":["octreotide-lanreotide"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"category":"Clinical"},"route":"/terms/carcinoid-syndrome/","neighbours":{"cancer":[{"id":"lung-net","kind":"cancer","name":"Lung neuroendocrine tumours (typical and atypical carcinoid)","route":"/cancers/lung-net/"},{"id":"neuroendocrine","kind":"cancer","name":"Neuroendocrine tumours","route":"/cancers/neuroendocrine/"},{"id":"small-intestinal-net","kind":"cancer","name":"Small intestinal neuroendocrine tumours","route":"/cancers/small-intestinal-net/"}],"drug":[{"id":"octreotide-lanreotide","kind":"drug","name":"Somatostatin analogues (octreotide, lanreotide)","route":"/drugs/octreotide-lanreotide/"}],"target":[{"id":"tph1","kind":"target","name":"Tryptophan hydroxylase 1","route":"/targets/tph1/"}]}}