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About 1 in 1,000 pregnancies is complicated by cancer, most often breast, cervical, lymphoma, melanoma or leukaemia. Most chemotherapy is safe after the first trimester, surgery is safe throughout, and ending the pregnancy does not improve the mother's outcome.
Incidence is rising with later childbearing. Principles (INCIP, ESMO 2013/2019 guidelines): staging with ultrasound and non-contrast MRI, avoid radiotherapy to the abdomen and most targeted/immune agents; surgery any trimester; anthracycline- and taxane-based chemotherapy from 14 weeks with delivery ≥3 weeks after the last cycle and not before 37 weeks where possible; no chemotherapy in the first trimester (malformation risk). The INCIP cohort showed children exposed in utero have normal cognitive and cardiac development at 3 and 6 years (Amant, NEJM 2015), with prematurity, not chemotherapy, driving outcomes. Trastuzumab (oligohydramnios), endocrine therapy, immunotherapy, TKIs and methotrexate are contraindicated or avoided. Pregnancy-associated breast cancer within a few years postpartum has worse biology. Placental metastasis is rare (melanoma most common).
One term page on OnCo cites this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing page listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.
One term page on OnCo cites this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing page listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.
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