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Cancer in people aged 15-39, about 90,000 US cases a year, with a distinct mix of cancers, slower survival improvement than children or older adults, and specific needs: fertility, education and work, psychosocial support and trial access.
AYA cancers include lymphoma, thyroid, testicular, melanoma, breast, colorectal (rising sharply in under-50s), sarcomas, leukaemia and CNS tumours. Survival gains lagged for decades (the 'AYA gap') because of low trial enrolment, delayed diagnosis, biology (e.g. Ph-like ALL, worse-prognosis sarcoma subtypes) and care fragmented between paediatric and adult systems; paediatric-inspired ALL regimens in AYAs improved survival (CALGB 10403). Dedicated AYA programmes (Teenage Cancer Trust UK, NCI AYA Oncology Progress Review Group 2006, COG/NCTN AYA committee) address fertility preservation, psychosocial care, financial toxicity, survivorship and age-appropriate environments. Early-onset colorectal and breast cancer incidence increases are a current research priority.
Shares Teenage Cancer Trust, Who gets told about fertility before treatment, and who does not, Who misses out on recovery care, measured, Oncofertility and fertility preservation.
Shares Teenage Cancer Trust, Oncofertility and fertility preservation, Testicular germ cell tumours, Ewing sarcoma.
Shares Who gets told about fertility before treatment, and who does not, Ovarian function after chemotherapy: who recovers, and when, Germ cell tumours of childhood and adolescence (extracranial and CNS), Oncofertility and fertility preservation.
Shares Who gets told about fertility before treatment, and who does not, Germ cell tumours of childhood and adolescence (extracranial and CNS), Oncofertility and fertility preservation, Testicular germ cell tumours.
Shares Teenage Cancer Trust, Testicular germ cell tumours, Ewing sarcoma, Osteosarcoma.
Shares Who gets told about fertility before treatment, and who does not, Ovarian function after chemotherapy: who recovers, and when, Oncofertility and fertility preservation, Survivorship care and late-effects surveillance.
Shares Oncofertility and fertility preservation, Testicular germ cell tumours, Survivorship care and late-effects surveillance, Late effects and survivorship toxicity.
Shares Ovarian function after chemotherapy: who recovers, and when, Adolescent and young adult cancers (ages 15 to 39), Hodgkin lymphoma, Acute lymphoblastic leukaemia.