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ZMIZ1 (Zinc finger MIZ domain-containing protein 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer, Prostate cancer and Colorectal cancer.
Acts as a transcriptional coactivator. Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation.
Open Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.91, genetic association 0.73).
In plain words · ZMIZ1 (Zinc finger MIZ domain-containing protein 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer, Prostate cancer and Colorectal cancer.
ZMIZ1 (Zinc finger MIZ domain-containing protein 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer, Prostate cancer and Colorectal cancer.
Acts as a transcriptional coactivator. Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation.
No product in this corpus aims at ZMIZ1 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1999. Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 1999, "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". Source.
Sources: HGNC HGNC:16493 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9ULJ6 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000108175 (association with cancer (MONDO_0004992) 0.58; per-cancer scores at or above 0.5: colorectal cancer 0.55, prostate cancer 0.55, breast cancer 0.56 (GraphQL API, CC0))
Acts as a transcriptional coactivator. Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation. Also functions as a transcriptional coactivator in the TGF-beta signalling pathway by increasing the activity of the SMAD3/SMAD4 transcriptional complex. Involved in transcriptional activation of a subset of NOTCH1 target genes including MYC. Involved in thymocyte and T cell development. Location: Nucleus, nucleoplasm; Cytoplasm; Nucleus (UniProt). Locus 10q22.3 (HGNC).
Query for this target: (TITLE:"ZMIZ1" OR ABSTRACT:"ZMIZ1" OR TITLE:"zinc finger MIZ-type containing 1" OR ABSTRACT:"zinc finger MIZ-type containing 1" OR TITLE:"Zinc finger MIZ domain-containing protein 1" OR ABSTRACT:"Zinc finger MIZ domain-containing protein 1" OR TITLE:"RP11-519K18.1" OR ABSTRACT:"RP11-519K18.1" OR TITLE:"KIAA1224" OR ABSTRACT:"KIAA1224" OR TITLE:"FLJ13541" OR ABSTRACT:"FLJ13541") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ZMIZ1, not a curated reading list.