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ZMIZ1 (Zinc finger MIZ domain-containing protein 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer, Prostate cancer and Colorectal cancer. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Acts as a transcriptional coactivator. Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation. Also functions as a transcriptional coactivator in the TGF-beta signalling pathway by increasing the activity of the SMAD3/SMAD4 transcriptional complex. Involved in transcriptional activation of a subset of NOTCH1 target genes including MYC. Involved in thymocyte and T cell development. Location: Nucleus, nucleoplasm; Cytoplasm; Nucleus (UniProt). Locus 10q22.3 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"ZMIZ1" OR ABSTRACT:"ZMIZ1" OR TITLE:"zinc finger MIZ-type containing 1" OR ABSTRACT:"zinc finger MIZ-type containing 1" OR TITLE:"Zinc finger MIZ domain-containing protein 1" OR ABSTRACT:"Zinc finger MIZ domain-containing protein 1" OR TITLE:"RP11-519K18.1" OR ABSTRACT:"RP11-519K18.1" OR TITLE:"KIAA1224" OR ABSTRACT:"KIAA1224" OR TITLE:"FLJ13541" OR ABSTRACT:"FLJ13541") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ZMIZ1, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/zmiz1.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/zmiz1.json. Licence CC BY-NC 4.0.