{"entity":{"id":"zmiz1","kind":"target","name":"ZMIZ1","aka":["zinc finger MIZ-type containing 1","Zinc finger MIZ domain-containing protein 1","RP11-519K18.1","KIAA1224","FLJ13541","hZIMP10","Zimp10","RAI17"],"tldr":"ZMIZ1 (Zinc finger MIZ domain-containing protein 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer, Prostate cancer and Colorectal cancer.","summary":"Acts as a transcriptional coactivator. Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation.\n\nOpen Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.91, genetic association 0.73).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:16493","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16493"},{"label":"UniProt Q9ULJ6","url":"https://www.uniprot.org/uniprotkb/Q9ULJ6/entry"},{"label":"NCBI Gene 57178","url":"https://www.ncbi.nlm.nih.gov/gene/57178"},{"label":"Ensembl ENSG00000108175","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000108175"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["breast-cancer","prostate","colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ZMIZ1","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:16493","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16493","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9ULJ6","url":"https://www.uniprot.org/uniprotkb/Q9ULJ6/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000108175","url":"https://platform.opentargets.org/target/ENSG00000108175/associations","note":"association with cancer (MONDO_0004992) 0.58; per-cancer scores at or above 0.5: colorectal cancer 0.55, prostate cancer 0.55, breast cancer 0.56 (GraphQL API, CC0)"}],"specificitySources":[],"hgnc":"HGNC:16493","ensembl":"ENSG00000108175","uniprot":"Q9ULJ6","entrez":"57178","firstDescribed":1999,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 1999, \"Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/10574462/","biology":"Acts as a transcriptional coactivator. Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation. Also functions as a transcriptional coactivator in the TGF-beta signalling pathway by increasing the activity of the SMAD3/SMAD4 transcriptional complex. Involved in transcriptional activation of a subset of NOTCH1 target genes including MYC. Involved in thymocyte and T cell development. Location: Nucleus, nucleoplasm; Cytoplasm; Nucleus (UniProt). Locus 10q22.3 (HGNC).","whereFound":["Breast cancer: Open Targets association 0.56 with breast cancer (MONDO_0007254)","Prostate cancer: Open Targets association 0.55 with prostate cancer (MONDO_0008315)","Colorectal cancer: Open Targets association 0.55 with colorectal cancer (MONDO_0005575)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/zmiz1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}]}}