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ZHX2 (Zinc fingers and homeoboxes protein 2) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Papillary renal cell carcinoma.
Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by NFYA. May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Sorafenib.
In plain words · ZHX2 (Zinc fingers and homeoboxes protein 2) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Papillary renal cell carcinoma.
ZHX2 (Zinc fingers and homeoboxes protein 2) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Papillary renal cell carcinoma.
Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by NFYA.
No product in this corpus aims at ZHX2 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA ZHX2: RNA low tissue specificity; high antibody staining in 13 normal tissues; highest cancer staining lymphoma (7 of 12 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Renal cell carcinoma); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas ZHX2 tissue; Open Targets ENSG00000178764 associations
First described 1998. Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 1998, "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". Source.
Sources: HGNC HGNC:18513 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9Y6X8 (protein name, function text, keywords and locations (REST API)); CIViC gene ZHX2 (1 evidence items, 0 assertions, 1 variants; diseases: Papillary Renal Cell Carcinoma (GraphQL API, CC0))
Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by NFYA. May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells. In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex. Location: Nucleus (UniProt). Locus 8q24.13 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
Medium: Adrenal gland, Colon, Endometrium, Fallopian tube, Heart muscle, Hippocampus, Kidney, Liver.
Medium only: colorectal cancer, head and neck cancer, lung cancer, melanoma.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"ZHX2" OR ABSTRACT:"ZHX2" OR TITLE:"zinc fingers and homeoboxes 2" OR ABSTRACT:"zinc fingers and homeoboxes 2" OR TITLE:"Zinc fingers and homeoboxes protein 2" OR ABSTRACT:"Zinc fingers and homeoboxes protein 2" OR TITLE:"KIAA0854" OR ABSTRACT:"KIAA0854") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ZHX2, not a curated reading list.
Shares Papillary renal cell carcinoma, CIViC.
Shares Papillary renal cell carcinoma, CIViC.
Shares Papillary renal cell carcinoma, CIViC.
Shares Papillary renal cell carcinoma, CIViC.
Shares Papillary renal cell carcinoma, CIViC.