{"entity":{"id":"zhx2","kind":"target","name":"ZHX2","aka":["zinc fingers and homeoboxes 2","Zinc fingers and homeoboxes protein 2","KIAA0854"],"tldr":"ZHX2 (Zinc fingers and homeoboxes protein 2) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Papillary renal cell carcinoma.","summary":"Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by NFYA. May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Sorafenib.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:18513","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18513"},{"label":"UniProt Q9Y6X8","url":"https://www.uniprot.org/uniprotkb/Q9Y6X8/entry"},{"label":"NCBI Gene 22882","url":"https://www.ncbi.nlm.nih.gov/gene/22882"},{"label":"Ensembl ENSG00000178764","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000178764"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["papillary-rcc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"ZHX2","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:18513","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18513","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9Y6X8","url":"https://www.uniprot.org/uniprotkb/Q9Y6X8/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene ZHX2","url":"https://civicdb.org/features/9121","note":"1 evidence items, 0 assertions, 1 variants; diseases: Papillary Renal Cell Carcinoma (GraphQL API, CC0)"}],"specificity":"broadly-expressed","distribution":"one-type","specificityNote":"Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA ZHX2: RNA low tissue specificity; high antibody staining in 13 normal tissues; highest cancer staining lymphoma (7 of 12 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Renal cell carcinoma); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"Human Protein Atlas ZHX2 tissue","url":"https://www.proteinatlas.org/ENSG00000178764-ZHX2/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000178764 associations","url":"https://platform.opentargets.org/target/ENSG00000178764/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:18513","ensembl":"ENSG00000178764","uniprot":"Q9Y6X8","entrez":"22882","firstDescribed":1998,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 1998, \"Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/10048485/","biology":"Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by NFYA. May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells. In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex. Location: Nucleus (UniProt). Locus 8q24.13 (HGNC).","whereFound":["Papillary renal cell carcinoma: CIViC evidence names this disease"],"targetClass":"transcription","prevalence":[]},"route":"/targets/zhx2/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"papillary-rcc","kind":"cancer","name":"Papillary renal cell carcinoma","route":"/cancers/papillary-rcc/"}]}}