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ZBTB48 (Zinc finger and BTB domain-containing protein 48) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Angiosarcoma.
Plays a critical role in transcriptional regulation and chromatin remodeling. Acts as a regulator of telomere length. Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat.
IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Angiosarcoma.
In plain words · ZBTB48 (Zinc finger and BTB domain-containing protein 48) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Angiosarcoma.
ZBTB48 (Zinc finger and BTB domain-containing protein 48) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Angiosarcoma.
Plays a critical role in transcriptional regulation and chromatin remodeling. Acts as a regulator of telomere length.
No product in this corpus aims at ZBTB48 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 1988. Earliest sequence paper UniProt cites for the protein: Ruppert J.M. et al, Mol. Cell. Biol, 1988, "The GLI-Kruppel family of human genes". Source.
Sources: HGNC HGNC:4930 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P10074 (protein name, function text, keywords and locations (REST API)); IntOGen ZBTB48 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Plays a critical role in transcriptional regulation and chromatin remodeling. Acts as a regulator of telomere length. Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres. Also acts as a transcription regulator that binds to promoter regions. Regulates expression of a small subset of genes, including MTFP1. Location: Nucleus; Chromosome, telomere (UniProt). Locus 1p36.31 (HGNC).
Query for this target: (TITLE:"ZBTB48" OR ABSTRACT:"ZBTB48" OR TITLE:"zinc finger and BTB domain containing 48" OR ABSTRACT:"zinc finger and BTB domain containing 48" OR TITLE:"Zinc finger and BTB domain-containing protein 48" OR ABSTRACT:"Zinc finger and BTB domain-containing protein 48" OR TITLE:"ZNF855" OR ABSTRACT:"ZNF855" OR TITLE:"HKR3" OR ABSTRACT:"HKR3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ZBTB48, not a curated reading list.
Shares Angiosarcoma, IntOGen.
Shares Angiosarcoma, IntOGen.
Shares Angiosarcoma, IntOGen.
Shares Angiosarcoma, IntOGen.
Shares Angiosarcoma, IntOGen.
Shares Angiosarcoma, IntOGen.