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ANK1 (Ankyrin-1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer, Prostate cancer, Angiosarcoma and 2 more.
Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane. Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions.
IntOGen calls it a driver in 7 cohorts (5 activating, 2 loss-of-function), covering Angiosarcoma, Cholangiocarcinoma, Colon Adenocarcinoma, Colorectal Adenocarcinoma, Lung Adenocarcinoma, Prostate Adenocarcinoma.
In plain words · ANK1 (Ankyrin-1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer, Prostate cancer, Angiosarcoma and 2 more.
ANK1 (Ankyrin-1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer, Prostate cancer, Angiosarcoma and 2 more.
Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane.
No product in this corpus aims at ANK1 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 1990. Earliest sequence paper UniProt cites for the protein: Lux S.E. et al, Nature, 1990, "Analysis of cDNA for human erythrocyte ankyrin indicates a repeated structure with homology to tissue-differentiation and cell-cycle control proteins". Source.
Sources: HGNC HGNC:492 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P16157 (protein name, function text, keywords and locations (REST API)); IntOGen ANK1 (driver in 7 cohorts (Act 5, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane. Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. Together with obscurin in skeletal muscle may provide a molecular link between the sarcoplasmic reticulum and myofibrils. Location: Cytoplasm, cytoskeleton; Membrane; Cytoplasm, myofibril, sarcomere, M line; Sarcoplasmic reticulum (UniProt). Locus 8p11.21 (HGNC).
Query for this target: (TITLE:"ANK1" OR ABSTRACT:"ANK1" OR TITLE:"ankyrin 1" OR ABSTRACT:"ankyrin 1" OR TITLE:"Ankyrin-1" OR ABSTRACT:"Ankyrin-1" OR TITLE:"SPH1" OR ABSTRACT:"SPH1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ANK1, not a curated reading list.
Shares Angiosarcoma, IntOGen.
Shares Angiosarcoma, IntOGen.
Shares Angiosarcoma, Biliary tract cancer (cholangiocarcinoma), IntOGen, Prostate cancer.
Shares Angiosarcoma, IntOGen.
Shares Angiosarcoma, IntOGen.
Shares Angiosarcoma, IntOGen, Prostate cancer.