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ABCC4 (ATP-binding cassette sub-family C member 4) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Angiosarcoma.
ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signalling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too.
IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Angiosarcoma.
In plain words · ABCC4 (ATP-binding cassette sub-family C member 4) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Angiosarcoma.
ABCC4 (ATP-binding cassette sub-family C member 4) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Angiosarcoma.
ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells.
No product in this corpus aims at ABCC4 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 1997. Earliest sequence paper UniProt cites for the protein: Kool et al, Cancer Res, 1997, "Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines". Source.
Sources: HGNC HGNC:55 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O15439 (protein name, function text, keywords and locations (REST API)); IntOGen ABCC4 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signalling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). May contribute to hepatic, intestinal and renal excretion of steroid conjugates. Location: Basolateral cell membrane; Apical cell membrane (UniProt). Locus 13q32.1 (HGNC).
Query for this target: (TITLE:"ABCC4" OR ABSTRACT:"ABCC4" OR TITLE:"ATP binding cassette subfamily C member 4 PEL blood group" OR ABSTRACT:"ATP binding cassette subfamily C member 4 PEL blood group" OR TITLE:"ATP-binding cassette sub-family C member 4" OR ABSTRACT:"ATP-binding cassette sub-family C member 4" OR TITLE:"MRP4" OR ABSTRACT:"MRP4" OR TITLE:"EST170205" OR ABSTRACT:"EST170205" OR TITLE:"MOAT-B" OR ABSTRACT:"MOAT-B") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ABCC4, not a curated reading list.
Shares Angiosarcoma, IntOGen.
Shares Angiosarcoma, IntOGen.
Shares Angiosarcoma, IntOGen.
Shares Angiosarcoma, IntOGen.
Shares Angiosarcoma, IntOGen.
Shares Angiosarcoma, IntOGen.