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RNF213 (E3 ubiquitin-protein ligase RNF213) is an enzyme. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer, Bladder & urothelial cancer, Renal cell carcinoma and 5 more.
Atypical E3 ubiquitin ligase that can catalyse ubiquitination of both proteins and lipids, and which is involved in various processes, such as lipid metabolism, angiogenesis and cell-autonomous immunity. Acts as a key immune sensor by catalysing ubiquitination of the lipid A moiety of bacterial lipopolysaccharide (LPS) via its RZ-type zinc-finger: restricts the proliferation of cytosolic bacteria, such as Salmonella, by generating the bacterial ubiquitin coat through the ubiquitination of LPS. Also acts indirectly by mediating the recruitment of the LUBAC complex, which conjugates linear polyubiquitin chains.
IntOGen calls it a driver in 11 cohorts (5 activating, 6 loss-of-function), covering Angiosarcoma, Bladder Urothelial Carcinoma, Renal Clear Cell Carcinoma, Cholangiocarcinoma, Oesophageal Adenocarcinoma, Glioblastoma Multiforme and others.
In plain words · RNF213 (E3 ubiquitin-protein ligase RNF213) is an enzyme. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer, Bladder & urothelial cancer, Renal cell carcinoma and 5 more.
RNF213 (E3 ubiquitin-protein ligase RNF213) is an enzyme. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer, Bladder & urothelial cancer, Renal cell carcinoma and 5 more.
Atypical E3 ubiquitin ligase that can catalyse ubiquitination of both proteins and lipids, and which is involved in various processes, such as lipid metabolism, angiogenesis and cell-autonomous immunity.
No product in this corpus aims at RNF213 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
First described 2000. Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 2000, "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". Source.
Sources: HGNC HGNC:14539 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q63HN8 (protein name, function text, keywords and locations (REST API)); IntOGen RNF213 (driver in 11 cohorts (Act 5, LoF 6); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Atypical E3 ubiquitin ligase that can catalyse ubiquitination of both proteins and lipids, and which is involved in various processes, such as lipid metabolism, angiogenesis and cell-autonomous immunity. Acts as a key immune sensor by catalysing ubiquitination of the lipid A moiety of bacterial lipopolysaccharide (LPS) via its RZ-type zinc-finger: restricts the proliferation of cytosolic bacteria, such as Salmonella, by generating the bacterial ubiquitin coat through the ubiquitination of LPS. Also acts indirectly by mediating the recruitment of the LUBAC complex, which conjugates linear polyubiquitin chains. Ubiquitination of LPS triggers cell-autonomous immunity, such as antibacterial autophagy, leading to degradation of the microbial invader. Also functions as an intracellular sensor for ISGylated proteins: upon type I interferon stimulation, undergoes ISGylation and oligomerises on lipid droplets to form a binding platform for ISG15-modified substrate proteins, thereby acting as a broad-spectrum antimicrobial effector. Restricts intracellular bacterial pathogens, such as Listeria monocytogenes, in an ISG15-dependent manner by decorating the bacterial surface with ubiquitin to promote autophagic clearance. Location: Cytoplasm, cytosol; Lipid droplet (UniProt). Locus 17q25.3 (HGNC).
Query for this target: (TITLE:"RNF213" OR ABSTRACT:"RNF213" OR TITLE:"ring finger protein 213" OR ABSTRACT:"ring finger protein 213" OR TITLE:"E3 ubiquitin-protein ligase RNF213" OR ABSTRACT:"E3 ubiquitin-protein ligase RNF213" OR TITLE:"KIAA1554" OR ABSTRACT:"KIAA1554" OR TITLE:"NET57" OR ABSTRACT:"NET57" OR TITLE:"ALO17" OR ABSTRACT:"ALO17") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RNF213, not a curated reading list.
Shares Angiosarcoma, Biliary tract cancer (cholangiocarcinoma), IntOGen, Prostate cancer.
Shares Clear cell renal cell carcinoma, Renal cell carcinoma, Biliary tract cancer (cholangiocarcinoma), Bladder & urothelial cancer.
Shares Clear cell renal cell carcinoma, Renal cell carcinoma, Oesophageal cancer, IntOGen.
Shares Clear cell renal cell carcinoma, Renal cell carcinoma, IntOGen.
Shares Clear cell renal cell carcinoma, Renal cell carcinoma, Oesophageal cancer, IntOGen.
Shares Clear cell renal cell carcinoma, Renal cell carcinoma, Bladder & urothelial cancer, IntOGen.
Shares Clear cell renal cell carcinoma, Endometrial cancer, Renal cell carcinoma, IntOGen.
Shares Clear cell renal cell carcinoma, Renal cell carcinoma, IntOGen.