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TNFRSF10B (Tumour necrosis factor receptor superfamily member 10B) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signalling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.
Open Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes genetic literature 0.30, clinical 0.20, literature 0.98, genetic association 0.79, animal model 0.27).
In plain words · TNFRSF10B (Tumour necrosis factor receptor superfamily member 10B) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
TNFRSF10B (Tumour necrosis factor receptor superfamily member 10B) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor.
No product in this corpus aims at TNFRSF10B yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA TNFRSF10B: RNA low tissue specificity; high antibody staining in 27 normal tissues; highest cancer staining liver cancer (3 of 12 high). Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 1 specific cancer type at or above 0.5 (basal cell carcinoma). (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas TNFRSF10B tissue; Open Targets ENSG00000120889 associations
First described 1997. Earliest sequence paper UniProt cites for the protein: Screaton G.R. et al, Curr. Biol, 1997, "TRICK2, a new alternatively spliced receptor that transduces the cytotoxic signal from TRAIL". Source.
Sources: HGNC HGNC:11905 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O14763 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000120889 (association with cancer (MONDO_0004992) 0.64; (GraphQL API, CC0))
Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signalling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis. Location: Membrane (UniProt). Locus 8p21.3 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
Medium: Cerebral cortex, Cervix, Endometrium, Esophagus, Fallopian tube, Lymph node, Nasopharynx, Oral mucosa.
Medium only: breast cancer, carcinoid, colorectal cancer, glioma.
HPA TNFRSF10B tissue · HPA TNFRSF10B pathology · HPA protein class: CD markers
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"TNFRSF10B" OR ABSTRACT:"TNFRSF10B" OR TITLE:"TNF receptor superfamily member 10b" OR ABSTRACT:"TNF receptor superfamily member 10b" OR TITLE:"Tumor necrosis factor receptor superfamily member 10B" OR ABSTRACT:"Tumor necrosis factor receptor superfamily member 10B" OR TITLE:"DR5" OR ABSTRACT:"DR5" OR TITLE:"KILLER" OR ABSTRACT:"KILLER" OR TITLE:"TRICK2A" OR ABSTRACT:"TRICK2A") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TNFRSF10B, not a curated reading list.
Shares Extrinsic apoptosis (death receptors), Open Targets Platform.
Shares Extrinsic apoptosis (death receptors), Open Targets Platform.