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TNFRSF10B (Tumour necrosis factor receptor superfamily member 10B) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signalling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis. Location: Membrane (UniProt). Locus 8p21.3 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"TNFRSF10B" OR ABSTRACT:"TNFRSF10B" OR TITLE:"TNF receptor superfamily member 10b" OR ABSTRACT:"TNF receptor superfamily member 10b" OR TITLE:"Tumor necrosis factor receptor superfamily member 10B" OR ABSTRACT:"Tumor necrosis factor receptor superfamily member 10B" OR TITLE:"DR5" OR ABSTRACT:"DR5" OR TITLE:"KILLER" OR ABSTRACT:"KILLER" OR TITLE:"TRICK2A" OR ABSTRACT:"TRICK2A") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TNFRSF10B, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/tnfrsf10b.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/tnfrsf10b.json. Licence CC BY-NC 4.0.