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TNFSF10 (Tumour necrosis factor ligand superfamily member 10) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.
Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 1.00, affected pathway 0.25, genetic association 0.62).
In plain words · TNFSF10 (Tumour necrosis factor ligand superfamily member 10) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
TNFSF10 (Tumour necrosis factor ligand superfamily member 10) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis.
No product in this corpus aims at TNFSF10 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1995. Earliest sequence paper UniProt cites for the protein: Wiley S.R. et al, Immunity, 1995, "Identification and characterization of a new member of the TNF family that induces apoptosis". Source.
Sources: HGNC HGNC:11925 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P50591 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000121858 (association with cancer (MONDO_0004992) 0.53; (GraphQL API, CC0))
Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. Location: Cell membrane; Secreted (UniProt). Locus 3q26.31 (HGNC).
Query for this target: (TITLE:"TNFSF10" OR ABSTRACT:"TNFSF10" OR TITLE:"TNF superfamily member 10" OR ABSTRACT:"TNF superfamily member 10" OR TITLE:"Tumor necrosis factor ligand superfamily member 10" OR ABSTRACT:"Tumor necrosis factor ligand superfamily member 10" OR TITLE:"TRAIL" OR ABSTRACT:"TRAIL" OR TITLE:"Apo-2L" OR ABSTRACT:"Apo-2L" OR TITLE:"TL2" OR ABSTRACT:"TL2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TNFSF10, not a curated reading list.
Shares Extrinsic apoptosis (death receptors), Open Targets Platform.
Shares Extrinsic apoptosis (death receptors), Open Targets Platform.