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TBL1XR1 (F-box-like/WD repeat-containing protein TBL1XR1) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-Hodgkin lymphoma, Leukaemia, Breast cancer and 5 more.
F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant. Open Targets scores its association with cancer at 0.68 (direct and indirect evidence; datatypes literature 0.96, animal model 0.28, genetic association 0.34, somatic mutation 0.83). IntOGen calls it a driver in 9 cohorts (8 activating, 1 loss-of-function), covering Acute Lymphoblastic Leukaemia, Burkitt Lymphoma, Invasive Breast Carcinoma, Diffuse Large B-Cell Lymphoma, NOS, Malignant Lymphoma, Non-Hodgkin Lymphoma and others.
In plain words · TBL1XR1 (F-box-like/WD repeat-containing protein TBL1XR1) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-Hodgkin lymphoma, Leukaemia, Breast cancer and 5 more.
TBL1XR1 (F-box-like/WD repeat-containing protein TBL1XR1) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-Hodgkin lymphoma, Leukaemia, Breast cancer and 5 more.
F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors.
No product in this corpus aims at TBL1XR1 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
Tumour-specific alteration: the catalogues call it an oncogene driver (IntOGen cohort analysis finds it activated more often than chance) and a tumour suppressor (IntOGen finds it knocked out more often than chance), so the direction differs between cohorts but the alteration is somatic either way; what a medicine would aim at or exploit is the altered form or its loss, absent from normal cells; no corpus medicine is aimed at it yet. HPA TBL1XR1: RNA low tissue specificity; high antibody staining in 43 normal tissues; highest cancer staining breast cancer (12 of 12 high). Distribution: 6 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Lymphoma, Leukaemia, Breast cancer (all types), Mesothelioma, Lung cancer (all types), Skin cancer (all types)); Open Targets associates it with 1 specific cancer type at or above 0.5 (diffuse large B-cell lymphoma). (Rule 6 of scripts/fetch-target-specificity.ts.)
Sources: UniProt Q9BZK7; CIViC gene TBL1XR1; IntOGen TBL1XR1; Human Protein Atlas TBL1XR1 tissue; Open Targets ENSG00000177565 associations
First described 2000. Earliest sequence paper UniProt cites for the protein: Zhang et al, Exp. Hematol, 2000, "Identification of four human cDNAs that are differentially expressed by early hematopoietic progenitors". Source.
Sources: HGNC HGNC:29529 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9BZK7 (protein name, function text, keywords and locations (REST API)); CIViC gene TBL1XR1 (1 evidence items, 0 assertions, 1 variants; diseases: Diffuse Large B-cell Lymphoma (GraphQL API, CC0)); Open Targets ENSG00000177565 (association with cancer (MONDO_0004992) 0.68; per-cancer scores at or above 0.5: melanoma 0.51, diffuse large B-cell lymphoma 0.67, non-Hodgkin lymphoma 0.74, skin cancer 0.52, breast cancer 0.58, lung cancer 0.52 (GraphQL API, CC0)); IntOGen TBL1XR1 (driver in 9 cohorts (Act 8, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation. Location: Nucleus (UniProt). Locus 3q26.32 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
Medium: Liver, Skeletal muscle.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"TBL1XR1" OR ABSTRACT:"TBL1XR1" OR TITLE:"TBL1X/Y related 1" OR ABSTRACT:"TBL1X/Y related 1" OR TITLE:"F-box-like/WD repeat-containing protein TBL1XR1" OR ABSTRACT:"F-box-like/WD repeat-containing protein TBL1XR1" OR TITLE:"IRA1" OR ABSTRACT:"IRA1" OR TITLE:"FLJ12894" OR ABSTRACT:"FLJ12894" OR TITLE:"TBLR1" OR ABSTRACT:"TBLR1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TBL1XR1, not a curated reading list.
Shares Leukaemia (all types), Skin cancer (all types), Acute lymphoblastic leukaemia, CIViC.
Shares Mesothelioma, Leukaemia (all types), Skin cancer (all types), CIViC.
Shares Leukaemia (all types), Skin cancer (all types), IntOGen, Lung cancer (all types).
Shares Leukaemia (all types), Skin cancer (all types), Acute lymphoblastic leukaemia, IntOGen.
Shares Leukaemia (all types), Acute lymphoblastic leukaemia, CIViC, IntOGen.
Shares Leukaemia (all types), Skin cancer (all types), Acute lymphoblastic leukaemia, CIViC.
Shares Leukaemia (all types), Skin cancer (all types), CIViC, IntOGen.
Shares Leukaemia (all types), Acute lymphoblastic leukaemia, CIViC, Breast cancer (all types).