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SSX2 (SSX family member 2) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Sarcomas and Synovial sarcoma.
Could act as a modulator of transcription.
Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.95, somatic mutation 0.97).
In plain words · SSX2 (SSX family member 2) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Sarcomas and Synovial sarcoma.
SSX2 (SSX family member 2) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Sarcomas and Synovial sarcoma.
Could act as a modulator of transcription. Location: Nucleus (UniProt).
No product in this corpus aims at SSX2 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1994. Earliest sequence paper UniProt cites for the protein: Clark et al, Nat. Genet, 1994, "Identification of novel genes, SYT and SSX, involved in the t(X;18)(p11.2;q11.2) translocation found in human synovial sarcoma". Source.
Sources: HGNC HGNC:11336 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q16385 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000241476 (association with cancer (MONDO_0004992) 0.62; per-cancer scores at or above 0.5: sarcoma 0.61, synovial sarcoma 0.53 (GraphQL API, CC0))
Could act as a modulator of transcription. Location: Nucleus (UniProt). Locus Xp11.22 (HGNC).
Query for this target: (TITLE:"SSX2" OR ABSTRACT:"SSX2" OR TITLE:"SSX family member 2" OR ABSTRACT:"SSX family member 2" OR TITLE:"HOM-MEL-40" OR ABSTRACT:"HOM-MEL-40" OR TITLE:"HD21" OR ABSTRACT:"HD21" OR TITLE:"MGC3884" OR ABSTRACT:"MGC3884" OR TITLE:"MGC15364" OR ABSTRACT:"MGC15364") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SSX2, not a curated reading list.
Shares Synovial sarcoma, Sarcomas (soft tissue, bone, GIST), Open Targets Platform.
Shares Synovial sarcoma, Sarcomas (soft tissue, bone, GIST), Open Targets Platform.
Shares Synovial sarcoma, Sarcomas (soft tissue, bone, GIST).
Shares Synovial sarcoma, Sarcomas (soft tissue, bone, GIST).
Shares Synovial sarcoma, Sarcomas (soft tissue, bone, GIST).
Shares Synovial sarcoma, Sarcomas (soft tissue, bone, GIST), Open Targets Platform.
Shares Synovial sarcoma, Sarcomas (soft tissue, bone, GIST).
Shares Synovial sarcoma, Sarcomas (soft tissue, bone, GIST).